Risedronate reduces postoperative bone resorption after cementless total hip arthroplasty: A systematic review and meta-analysis

Abstract

Objective: To examine the effects of risedronate for reducing periprosthetic bone loss after total hip arthroplasty (THA).

Methods: Two reviewers performed an electronic literature search for randomized controlled trial (RCTs) evaluating the risedronate in the management of periprosthetic bone loss after primary THA. The electronic databases include PubMed, Medline, Embase, Web of Science and the Cochrane Library from inception to January 2018. We assessed the risk of bias using the Cochrane risk-of-bias tool. STATA 14.0 was used to perform the meta-analysis.

Results: Four RCTs were included in our study. Current meta-analysis indicated that postoperative reduciton of periprosthetic BMD in the risedronate group was significantly lower than that in the placebo group in zones 1, 2, 3, 4, 6, and 7. There was no increased risk of adverse effects.

Conclusion: The administration of risedronate was associates with a significantly improved periprosthetic BMD after primary THA. No increased risk of adverse events were observed. Higher quality RCTs are still required for further research.

Keywords: Bisphosphonate; Bone mineral density; Bone resorption; Total hip arthroplasty.