Radiotherapy Controversies and Prospective in Head and Neck Cancer: A Literature-Based Critical Review

Francesca De Felice¹, Antonella Polimeni², Valentino Valentini³, Orlando Brugnoletti⁴, Andrea Cassoni⁵, Antonio Greco⁶, Marco de Vincentiis⁷, Vincenzo Tombolini⁸

Affiliations

¹ Department of Radiotherapy, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy. Electronic address: fradefelice@hotmail.it.
² Department of Oral and Maxillo Facial Sciences, Policlinico Umberto I "Sapienza" University of Rome, Italy. Electronic address: antonella.polimeni@uniroma1.it.
³ Department of Oral and Maxillo Facial Sciences, Policlinico Umberto I "Sapienza" University of Rome, Italy. Electronic address: valentino.valentini@uniroma1.it.
⁴ Department of Oral and Maxillo Facial Sciences, Policlinico Umberto I "Sapienza" University of Rome, Italy. Electronic address: orlando.brugnoletti@uniroma1.it.
⁵ Department of Oral and Maxillo Facial Sciences, Policlinico Umberto I "Sapienza" University of Rome, Italy. Electronic address: andrea.cassoni@uniroma1.it.
⁶ Department of Sense Organs, Policlinico Umberto I "Sapienza" University of Rome, Italy. Electronic address: antonio.greco@uniroma1.it.
⁷ Department of Oral and Maxillo Facial Sciences, Policlinico Umberto I "Sapienza" University of Rome, Italy. Electronic address: marco.devincentiis@uniroma1.it.
⁸ Department of Radiotherapy, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy. Electronic address: vincenzo.tombolini@uniroma1.it.

PMID: 29448084
PMCID: PMC5849807
DOI: 10.1016/j.neo.2018.01.002

Review

Radiotherapy Controversies and Prospective in Head and Neck Cancer: A Literature-Based Critical Review

Francesca De Felice et al. Neoplasia. 2018 Mar.

. 2018 Mar;20(3):227-232.

doi: 10.1016/j.neo.2018.01.002. Epub 2018 Feb 12.

Authors

Francesca De Felice¹, Antonella Polimeni², Valentino Valentini³, Orlando Brugnoletti⁴, Andrea Cassoni⁵, Antonio Greco⁶, Marco de Vincentiis⁷, Vincenzo Tombolini⁸

Affiliations

¹ Department of Radiotherapy, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy. Electronic address: fradefelice@hotmail.it.
² Department of Oral and Maxillo Facial Sciences, Policlinico Umberto I "Sapienza" University of Rome, Italy. Electronic address: antonella.polimeni@uniroma1.it.
³ Department of Oral and Maxillo Facial Sciences, Policlinico Umberto I "Sapienza" University of Rome, Italy. Electronic address: valentino.valentini@uniroma1.it.
⁴ Department of Oral and Maxillo Facial Sciences, Policlinico Umberto I "Sapienza" University of Rome, Italy. Electronic address: orlando.brugnoletti@uniroma1.it.
⁵ Department of Oral and Maxillo Facial Sciences, Policlinico Umberto I "Sapienza" University of Rome, Italy. Electronic address: andrea.cassoni@uniroma1.it.
⁶ Department of Sense Organs, Policlinico Umberto I "Sapienza" University of Rome, Italy. Electronic address: antonio.greco@uniroma1.it.
⁷ Department of Oral and Maxillo Facial Sciences, Policlinico Umberto I "Sapienza" University of Rome, Italy. Electronic address: marco.devincentiis@uniroma1.it.
⁸ Department of Radiotherapy, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy. Electronic address: vincenzo.tombolini@uniroma1.it.

PMID: 29448084
PMCID: PMC5849807
DOI: 10.1016/j.neo.2018.01.002

Abstract

In treating head and neck cancer (HNC), the objectives are provided for best functional results and minimal risk of serious complications. The choice of appropriate management depends primarily on specific site and stage of primary tumor at diagnosis. Radiation therapy (RT) with or without concomitant chemotherapy represents a classical treatment option. In this review, we provide an update of recent research strategies to counteract the existing damage caused by RT and highlight clinical trials currently in progress. We discuss the challenges in the evaluation of new stage system and RT-related toxicity onset. We mainly address the deficiencies and the advantages noted in the current treatment era.

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References

1. Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2017. CA Cancer J Clin. 2017;67(1):7–30. - PubMed
1. Marur S, Forastiere AA. Head and Neck Squamous Cell Carcinoma: Update on Epidemiology, Diagnosis, and Treatment. Mayo Clin Proc. 2016;91(3):386–396. - PubMed
1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65(2):87–108. - PubMed
1. AIOM . I numeri del cancro in Italia. Il Pensiero Scientifico; 2016. AIRTUM.
1. Wuthrick EJ, Zhang Q, Machtay M, Rosenthal DI, Nguyen-Tan PF, Fortin A, Silverman CL, Raben A, Kim HE, Horwitz EM. Institutional clinical trial accrual volume and survival of patients with head and neck cancer. J Clin Oncol. 2015;33(2):156–164. - PMC - PubMed

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Radiotherapy Controversies and Prospective in Head and Neck Cancer: A Literature-Based Critical Review

Affiliations

Radiotherapy Controversies and Prospective in Head and Neck Cancer: A Literature-Based Critical Review

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases