An official website of the United States government
The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before
sharing sensitive information, make sure you’re on a federal
government site.
The site is secure.
The https:// ensures that you are connecting to the
official website and that any information you provide is encrypted
and transmitted securely.
1 From the Institute for Translational Medicine and Therapeutics (T.G., G.A.F.) and Department of Surgery (A.N.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.
2 From the Institute for Translational Medicine and Therapeutics (T.G., G.A.F.) and Department of Surgery (A.N.), Perelman School of Medicine, University of Pennsylvania, Philadelphia. garret@upenn.edu.
1 From the Institute for Translational Medicine and Therapeutics (T.G., G.A.F.) and Department of Surgery (A.N.), Perelman School of Medicine, University of Pennsylvania, Philadelphia.
2 From the Institute for Translational Medicine and Therapeutics (T.G., G.A.F.) and Department of Surgery (A.N.), Perelman School of Medicine, University of Pennsylvania, Philadelphia. garret@upenn.edu.
Mitchell JA, Knowles RB, Kirkby NS, Reed DM, Edin ML, White WE, Chan MV, Longhurst H, Yaqoob MM, Milne GL, Zeldin DC, Warner TD.Mitchell JA, et al.Circ Res. 2018 Feb 16;122(4):555-559. doi: 10.1161/CIRCRESAHA.117.312144. Epub 2018 Jan 3.Circ Res. 2018.PMID: 29298774Free PMC article.
References
FitzGerald GA, Pedersen AK, Patrono C. Analysis of prostacyclin and thromboxane biosynthesis in cardiovascular disease. Circulation. 1983;67:1174–1177.
-
PubMed
Grosser T, Fries S, FitzGerald GA. Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities. J Clin Invest. 2006;116:4–15.
-
PMC
-
PubMed
Samuelsson B, Granström E, Green K, Hamberg M, Hammarström S. Prostaglandins. Annu Rev Biochem. 1975;44:669–95.
-
PubMed
Patrono C, Ciabattoni G, Pugliese F, Pierucci A, Blair IA, FitzGerald GA. Estimated rate of thromboxane secretion into the circulation of normal humans. J Clin Invest. 1986;77:590–4.
-
PMC
-
PubMed
Remuzzi G, Benigni A, Dodesini P, Schieppati A, Livio M, De Gaetano G, Day SS, Smith WL, Pinca E, Patrignani P, Patrono C. Reduced platelet thromboxane formation in uremia. Evidence for a functional cyclooxygenase defect. J Clin Invest. 1983;71:762–8.
-
PMC
-
PubMed