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Editorial
. 2018 Feb 16;122(4):540-542.
doi: 10.1161/CIRCRESAHA.118.312654.

The Cellular Origin of Activated Fibroblasts in the Infarcted and Remodeling Myocardium

Linda Alex  1 , Nikolaos G Frangogiannis  2
Affiliations
Editorial

The Cellular Origin of Activated Fibroblasts in the Infarcted and Remodeling Myocardium

Linda Alex et al. Circ Res. .
No abstract available

Keywords: Editorials; extracellular matrix; fibroblast; inflammation; leukocyte; myocardial infarction.

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Figures

FIGURE
FIGURE
Schematic cartoon illustrating the origin of activated fibroblasts in the infarcted myocardium. Although 2 independent studies using BM transplantation strategies suggested that up to a quarter of infarct fibroblasts may be derived from the BM,, the bulk of the evidence suggests very low numbers of BM-derived fibroblasts in the infarcted myocardium,,, Lineage tracing strategies documented that intracardiac interstitial cells (Tcf21+ fibroblasts, or epicardial-derived interstitial cells) are the predominant source of infarct fibroblasts,,. Although a study investigating the contribution of Gli-1+ cells in tissue fibrosis suggested that 60% of infarct myofibroblasts are derived from perivascular cells, the role of the pericytes (and the potential overlap between fibroblast and pericyte populations) remains understudied. In some studies, endothelial cells (EC) were found to be a major source of infarct fibroblasts, whereas other investigations showed very low numbers of endothelial-derived fibroblasts in the infarct,. Conflicting findings reflect the use of different approaches to trace the cells, and the absence of reliable and specific markers to identify fibroblasts.
See this image and copyright information in PMC

Comment on

  • Infarct Fibroblasts Do Not Derive From Bone Marrow Lineages.
    Moore-Morris T, Cattaneo P, Guimarães-Camboa N, Bogomolovas J, Cedenilla M, Banerjee I, Ricote M, Kisseleva T, Zhang L, Gu Y, Dalton ND, Peterson KL, Chen J, Pucéat M, Evans SM. Moore-Morris T, et al. Circ Res. 2018 Feb 16;122(4):583-590. doi: 10.1161/CIRCRESAHA.117.311490. Epub 2017 Dec 21. Circ Res. 2018. PMID: 29269349 Free PMC article.

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