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Comment
. 2018 Jan 15;32(2):93-95.
doi: 10.1101/gad.311357.118.

'Big bang' of B-cell development revealed

Cornelis Murre  1
Affiliations
Comment

'Big bang' of B-cell development revealed

Cornelis Murre. Genes Dev. .

Abstract

Earlier studies have identified transcription factors that specify B-cell fate, but the underlying mechanisms remain to be revealed. Two new studies by Miyai and colleagues (pp. 112-126) and Li and colleagues (pp. 96-111) in this issue of Genes & Development provide new and unprecedented insights into the genetic and epigenetic mechanisms that establish B-cell identity.

Keywords: B-cell differentiation; B-cell programming; EBF1; IRF4; Pax5; chromatin; epigenetics; transcription factor.

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Figures

Figure 1.
Figure 1.
Schematic diagram depicting the roles of transcriptional regulators during hematopoiesis. Distinct developmental stages are indicated. Transcription factors associated with developmental checkpoints are shown. (Mac) Macrophages; (Neu) neutrophils; (DN) CD4−CD8− thymocytes; (DP) CD4+CD8+ thymocytes. LT-HSCs, MPPs, LMPPs, ALPs, and BLPs are described in the text.
See this image and copyright information in PMC

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References

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