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Comment
. 2018 Feb 16;359(6377):740-741.
doi: 10.1126/science.aas8993.

Controlling learning and epilepsy together

Helen E Scharfman  1   2
Affiliations
Comment

Controlling learning and epilepsy together

Helen E Scharfman. Science. .
No abstract available

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Figures

None
Linking seizures and memory
MCs excite GCs and GABAergic neurons, which MCs excite GCs and GABAergic neurons, which inhibit GCs. Thus, MCs can activate many GCs or inhibit GCs. Thus, MCs can activate many GCs or they can inhibit them, via GABAergic neurons such they can inhibit them, via GABAergic neurons such as basket cells. This cellular circuitry can excite manyas basket cells. This cellular circuitry can excite many parts of the DG, potentially leading to activation ofparts of the DG, potentially leading to activation of CA3 pyramidal cells in the hippocampus and theirCA3 pyramidal cells in the hippocampus and their downstream targets, to initiate a seizure. downstream targets, to initiate a seizure.
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References

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