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. 2013 Oct 3:1:11-16.
doi: 10.1016/j.ijchv.2013.09.001. eCollection 2013 Dec.

Gender related predictors of limited exercise capacity in heart failure

Gani Bajraktari  1   2 , Ilir Kurtishi  3 , Nehat Rexhepaj  1 , Rina Tafarshiku  1 , Pranvera Ibrahimi  2 , Fisnik Jashari  2 , Rrezarta Alihajdari  1 , Arlind Batalli  1 , Shpend Elezi  4 , Michael Y Henein  2
Affiliations

Gender related predictors of limited exercise capacity in heart failure

Gani Bajraktari et al. Int J Cardiol Heart Vessel. .

Abstract

Aim: The aim of this study was to investigate the impact of gender on the prediction of limited exercise capacity in heart failure (HF) patients assessed by 6 minute walk test (6-MWT).

Methods: In 147 HF patients (mean age 61 ± 11 years, 50.3% male), a 6-MWT and a Doppler echocardiographic study were performed in the same day. Conventional cardiac measurements were obtained and global LV dyssynchrony was indirectly assessed using total isovolumic time - t-IVT [in s/min; calculated as: 60 - (total ejection time - total filling time)] and Tei index (t-IVT/ejection time). Patients were divided into two groups according to gender, which were again divided into two subgroups based on the 6-MWT distance (Group I: ≤ 300 m, and Group II: > 300 m).

Results: Female patients were younger (p = 0.02), and had higher left ventricular (LV) ejection fraction - EF (p = 0.007) but with similar 6-MWT distance to male patients (p = 68). Group I male patients had lower hemoglobin level (p = 0.02) and lower EF (p = 0.03), compared with Group II, but none of the clinical or echocardiographic variables differed between groups in female patients. In multivariate analysis, only t-IVT [0.699 (0.552-0.886), p = 0.003], and LV EF [0.908 (0.835-0.987), p = 0.02] in males, and NYHA functional class [4.439 (2.213-16.24), p = 0.02] in females independently predicted poor 6-MWT distance (< 300 m).

Conclusion: Despite similar limited exercise capacity, gender determines the pattern of underlying cardiac disturbances; ventricular dysfunction in males and subjective NYHA class in female heart failure patients.

Keywords: Doppler echocardiography; Gender; LV function and dyssynchrony; Six-minute walk test.

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References

    1. Lloyd-Jones D., Adams R., Carnethon M., De Simone G., Ferguson T.B., Flegal K., American Heart Association Statistics Committee and Stroke Statistics Subcommittee Heart disease and stroke statistics — 2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation. 2009;119:480–486. - PubMed
    1. Weir R.A., McMurray J.J. Epidemiology of heart failure and left ventricular dysfunction after acute myocardial infarction. Curr Heart Fail Rep. 2006;3:175–180. - PubMed
    1. Davies M., Hobbs F., Davis R., Kenkre J., Roalfe A.K., Hare R. Prevalence of left-ventricular systolic dysfunction and heart failure in the Echocardiographic Heart of England Screening study: a population based study. Lancet. 2001;358:439–445. - PubMed
    1. Ho K.K., Anderson K.M., Kannel W.B., Grossman W., Levy D. Survival after onset of congestive heart failure in Framingham Heart Study subjects. Circulation. 1993;88:107–115. - PubMed
    1. Packer M., Coats A.J., Fowler M.B., Katus H.A., Krum H., Mohacsi P. Effect of carvedilol on survival in severe chronic heart failure. N Engl J Med. 2001;344:1651–1658. - PubMed