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. 2018 Mar 20;319(11):1125-1133.
doi: 10.1001/jama.2018.1742.

Neurological Manifestations Among US Government Personnel Reporting Directional Audible and Sensory Phenomena in Havana, Cuba

Randel L Swanson 2nd  1   2 , Stephen Hampton  1   2 , Judith Green-McKenzie  2   3 , Ramon Diaz-Arrastia  2   4 , M Sean Grady  2   5 , Ragini Verma  2   6 , Rosette Biester  1   2 , Diana Duda  2   7 , Ronald L Wolf  2   6 , Douglas H Smith  2   5
Affiliations

Neurological Manifestations Among US Government Personnel Reporting Directional Audible and Sensory Phenomena in Havana, Cuba

Randel L Swanson 2nd et al. JAMA. .

Abstract

Importance: From late 2016 through August 2017, US government personnel serving on diplomatic assignment in Havana, Cuba, reported neurological symptoms associated with exposure to auditory and sensory phenomena.

Objective: To describe the neurological manifestations that followed exposure to an unknown energy source associated with auditory and sensory phenomena.

Design, setting, and participants: Preliminary results from a retrospective case series of US government personnel in Havana, Cuba. Following reported exposure to auditory and sensory phenomena in their homes or hotel rooms, the individuals reported a similar constellation of neurological symptoms resembling brain injury. These individuals were referred to an academic brain injury center for multidisciplinary evaluation and treatment.

Exposures: Report of experiencing audible and sensory phenomena emanating from a distinct direction (directional phenomena) associated with an undetermined source, while serving on US government assignments in Havana, Cuba, since 2016.

Main outcomes and measures: Descriptions of the exposures and symptoms were obtained from medical record review of multidisciplinary clinical interviews and examinations. Additional objective assessments included clinical tests of vestibular (dynamic and static balance, vestibulo-ocular reflex testing, caloric testing), oculomotor (measurement of convergence, saccadic, and smooth pursuit eye movements), cognitive (comprehensive neuropsychological battery), and audiometric (pure tone and speech audiometry) functioning. Neuroimaging was also obtained.

Results: Of 24 individuals with suspected exposure identified by the US Department of State, 21 completed multidisciplinary evaluation an average of 203 days after exposure. Persistent symptoms (>3 months after exposure) were reported by these individuals including cognitive (n = 17, 81%), balance (n = 15, 71%), visual (n = 18, 86%), and auditory (n = 15, 68%) dysfunction, sleep impairment (n = 18, 86%), and headaches (n = 16, 76%). Objective findings included cognitive (n = 16, 76%), vestibular (n = 17, 81%), and oculomotor (n = 15, 71%) abnormalities. Moderate to severe sensorineural hearing loss was identified in 3 individuals. Pharmacologic intervention was required for persistent sleep dysfunction (n = 15, 71%) and headache (n = 12, 57%). Fourteen individuals (67%) were held from work at the time of multidisciplinary evaluation. Of those, 7 began graduated return to work with restrictions in place, home exercise programs, and higher-level work-focused cognitive rehabilitation.

Conclusions and relevance: In this preliminary report of a retrospective case series, persistent cognitive, vestibular, and oculomotor dysfunction, as well as sleep impairment and headaches, were observed among US government personnel in Havana, Cuba, associated with reports of directional audible and/or sensory phenomena of unclear origin. These individuals appeared to have sustained injury to widespread brain networks without an associated history of head trauma.

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Conflict of interest statement

Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Dr Green-McKenzie reported receiving grants from Health Resources and Services Administration and the National Institute for Occupational Safety and Health. No other disclosures were reported.

Comment in

References

    1. US Senate Committee on Foreign Relations, Subcommittee on Western Hemisphere, Transnational Crime, Civilian Security, Democracy, Human Rights, and Global Women's Issues Attacks on US diplomats in Cuba. https://www.foreign.senate.gov/hearings/attacks-on-us-diplomats-in-cuba-.... Published January 9, 2018. Accessed February 8, 2018.
    1. Goodglass H, Kaplan E, Barresi B. Boston Diagnostic Aphasia Examination. 3rd ed Philadelphia, PA: Lippincott Williams & Wilkins; 2001.
    1. Delis D, Kramer J, Kaplan E, Ober B. The California Verbal Learning Test: CVLT-II. 2nd ed San Antonio, TX: Psychological Corp; 2000.
    1. Brown SG, Roy EA, Rohr LE, Snider BR, Bryden PJ. Preference and performance measures of handedness. Brain Cogn. 2004;55(2):283-285. - PubMed
    1. Tombaugh TN. Test of Memory Malingering. North Tonawanda, NY: Multi-Health Systems; 1996.

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