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Review
. 2018 Apr;42(4):668-677.
doi: 10.1111/acer.13612. Epub 2018 Mar 8.

Circadian Mechanisms in Alcohol Use Disorder and Tissue Injury

Booker T Davis 4th  1 , Robin M Voigt  1 , Maliha Shaikh  1 , Christopher B Forsyth  1 , Ali Keshavarzian  2
Affiliations
Review

Circadian Mechanisms in Alcohol Use Disorder and Tissue Injury

Booker T Davis 4th et al. Alcohol Clin Exp Res. 2018 Apr.

Abstract

Heavy use of alcohol can lead to addictive behaviors and to eventual alcohol-related tissue damage. While increased consumption of alcohol has been attributed to various factors including level of alcohol exposure and environmental factors such as stress, data from behavioral scientists and physiological researchers are revealing roles for the circadian rhythm in mediating the development of behaviors associated with alcohol use disorder as well as the tissue damage that drives physiological disease. In this work, we compile recent work on the complex mutually influential relationship that exists between the core circadian rhythm and the pharmacodynamics of alcohol. As we do so, we highlight implications of the relationship between alcohol and common circadian mechanisms of effected organs on alcohol consumption, metabolism, toxicity, and pathology.

Keywords: Alcohol; Alcohol Tissue Damage; Alcohol Use Disorder; Circadian Rhythm; PER2.

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Figures

Figure 1
Figure 1
Main Protein Components of Core Circadian Clock The core circadian clock is a transcriptional-translational feedback loop that is modulated Circadian rhythms are generated by intracellular transcriptional-transcriptional feedback loops that temporally synchronizes or separates biological processes through interaction, modification, and trafficking of proteins.
Figure 2
Figure 2
Role of Core Circadian Clock in Alcohol-Induced Pathology: Alcohol mediates disruption of circadian rhythm mechanism(s) inducing the increased intestinal permeability that is critical to the development and progression of alcoholic liver disease.
See this image and copyright information in PMC

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