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Meta-Analysis
. 2018 Jun 3;14(6):1453-1463.
doi: 10.1080/21645515.2018.1435224. Epub 2018 Feb 26.

Serotype distribution of Streptococcus pneumoniae and potential impact of pneumococcal conjugate vaccines in China: A systematic review and meta-analysis

Kaile Chen  1   2 , Xiyan Zhang  1   2 , Wei Shan  1   2 , Genming Zhao  1   2 , Tao Zhang  1   2
Affiliations
Meta-Analysis

Serotype distribution of Streptococcus pneumoniae and potential impact of pneumococcal conjugate vaccines in China: A systematic review and meta-analysis

Kaile Chen et al. Hum Vaccin Immunother. .

Abstract

Objective: Thirteen-valent pneumococcal conjugate vaccines (PCV13) was licensed for optional use in mainland China since 2017, but the uptake is low. To update the research evidence for the pneumococcal serotype distribution of pre-PCV era and to estimate the potential impact of PCVs, we performed a meta-analysis on the relevant publications concerning the Chinese population.

Methods: This systematic review and meta-analysis were conducted on the pneumococcal serotype distribution publications in mainland China from 2000 to 2016. The literature was searched in PubMed, Ovid-EMBASE, Web of Science, CNKI and Wanfang. Heterogeneity and publication bias were tested by I2, meta-regression, Egger's and Begg's test. The pneumococcal serotype and vaccine serotype coverage rates were pooled using the random-effects model in Stata SE 12.0.

Results: In total, 85 publications were included. Of all 16,945 included pneumococcal isolates, the most common serotypes/serogroups were 19F, 19A, 23F, 14, and 6B, that from children were the same as above, that from adults≥18 years were 19, 3, 6, 23, and 14. Among isolates from children <18 years, the pooled coverage for PCV10 serotypes was 52.3%, that for PCV13 was 68.4% and that for PPSV23 was 65.5%. Regarding individuals ≥18 years, the pooled coverage for PCV10 serotypes was 29.7%, that for PCV13 was 49.5% and that for PPSV23 was 50.7%. Serotype prevalence and vaccine serotype coverage varied by age group, source, and region.

Conclusions: The most common pneumococcal serotype in mainland China was 19F. The serotype coverage rates of PCV13 and PPSV23 were 50%-68% in mainland China.

Keywords: China; Streptococcus pneumoniae; pneumococcal conjugate vaccine; pneumococcal polysaccharide vaccine; serotype.

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Figures

Figure 1.
Figure 1.
Selection of Articles for Meta-analysis.
Figure 2.
Figure 2.
The regional distribution of enrolled studies and pneumococcal isolates.
Figure 3.
Figure 3.
Distribution of vaccine serotypes of pneumococcal isolates from 1996 to 2016 in mainland China.
See this image and copyright information in PMC

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