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. 2018 Mar 15:248:1-4.
doi: 10.1016/j.virusres.2018.02.010. Epub 2018 Feb 13.

Proposal for a new subtype of the zoonotic genotype 3 Hepatitis E virus: HEV-3l

Luca De Sabato  1 , Philippe Lemey  2 , Bram Vrancken  3 , Lebana Bonfanti  4 , Letizia Ceglie  4 , Gabriele Vaccari  5 , Ilaria Di Bartolo  6
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Proposal for a new subtype of the zoonotic genotype 3 Hepatitis E virus: HEV-3l

Luca De Sabato et al. Virus Res. .

Abstract

The near-complete genomic sequences of two hepatitis E virus (HEV) strains, detected from feces of infected pigs, were obtained. Phylogenetic analysis and p-distance comparisons of the complete coding regions showed a close relationship to the French swine strain FR-SHEV3c-like detected in 2006 (p-distance value 0.101), belonging to HEV-3 but not assigned to any known subtype. The three HEV sequences showed, relatively high nucleotide distances (p-distance >0.129) compared to the other defined HEV subtype references and unclassified strains. The HEV classification criteria and the high sequence similarity suggest that these strains can be assigned to a putative novel subtype of genotype 3, HEV-3l.

Keywords: Complete genome; Genotype 3; Hepatitis E virus; Next generation sequencing; Subtype; Swine.

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