Identification of clinically relevant chronic rhinosinusitis endotypes using cluster analysis of mucus cytokines

Justin H Turner¹, Rakesh K Chandra², Ping Li², Kemberlee Bonnet³, David G Schlundt³

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University School of Medicine, Nashville, Tenn. Electronic address: justin.h.turner@vanderbilt.edu.
² Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University School of Medicine, Nashville, Tenn.
³ Department of Psychological Sciences, Vanderbilt University School of Arts and Sciences, Nashville, Tenn; Vanderbilt Center for Qualitative Research, Nashville, Tenn.

PMID: 29452200
PMCID: PMC5938108
DOI: 10.1016/j.jaci.2018.02.002

Identification of clinically relevant chronic rhinosinusitis endotypes using cluster analysis of mucus cytokines

Justin H Turner et al. J Allergy Clin Immunol. 2018 May.

. 2018 May;141(5):1895-1897.e7.

doi: 10.1016/j.jaci.2018.02.002. Epub 2018 Feb 13.

Authors

Justin H Turner¹, Rakesh K Chandra², Ping Li², Kemberlee Bonnet³, David G Schlundt³

Affiliations

¹ Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University School of Medicine, Nashville, Tenn. Electronic address: justin.h.turner@vanderbilt.edu.
² Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University School of Medicine, Nashville, Tenn.
³ Department of Psychological Sciences, Vanderbilt University School of Arts and Sciences, Nashville, Tenn; Vanderbilt Center for Qualitative Research, Nashville, Tenn.

PMID: 29452200
PMCID: PMC5938108
DOI: 10.1016/j.jaci.2018.02.002

No abstract available

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Conflict of interest statement

Conflicts of interest: None

Figures

**Figure 1. Identification of inflammatory endotypes using cluster analysis of CRS mucus**
(A) Dendogram representing hierarchical cluster analysis of CRS patients based on principal component analysis of 18 mucus-derived biological variables. (B) Mean factor scores for each of the 6 CRS Clusters. (C) Asthma/polyp prevalence and differences in mucus cytokine levels among each of the 6 CRS clusters, compared to healthy controls. CRSwNP, chronic rhinosinusitis with nasal polyps; PC, principal component.

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References

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Identification of clinically relevant chronic rhinosinusitis endotypes using cluster analysis of mucus cytokines

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Identification of clinically relevant chronic rhinosinusitis endotypes using cluster analysis of mucus cytokines

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