Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 May;141(5):1895-1897.e7.
doi: 10.1016/j.jaci.2018.02.002. Epub 2018 Feb 13.

Identification of clinically relevant chronic rhinosinusitis endotypes using cluster analysis of mucus cytokines

Justin H Turner  1 , Rakesh K Chandra  2 , Ping Li  2 , Kemberlee Bonnet  3 , David G Schlundt  3
Affiliations

Identification of clinically relevant chronic rhinosinusitis endotypes using cluster analysis of mucus cytokines

Justin H Turner et al. J Allergy Clin Immunol. 2018 May.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest: None

Figures

Figure 1
Figure 1. Identification of inflammatory endotypes using cluster analysis of CRS mucus
(A) Dendogram representing hierarchical cluster analysis of CRS patients based on principal component analysis of 18 mucus-derived biological variables. (B) Mean factor scores for each of the 6 CRS Clusters. (C) Asthma/polyp prevalence and differences in mucus cytokine levels among each of the 6 CRS clusters, compared to healthy controls. CRSwNP, chronic rhinosinusitis with nasal polyps; PC, principal component.
See this image and copyright information in PMC

References

    1. Tan BK, Klingler AI, Poposki JA, Stevens WW, Peters AT, Suh LA, et al. Heterogeneous inflammatory patterns in chronic rhinosinusitis without nasal polyps in Chicago, Illinois. J Allergy Clin Immunol. 2017;139:699–703e7. - PMC - PubMed
    1. Stevens WW, Ocampo CJ, Berdnikovs S, Sakashita M, Mahdavinia M, Suh L, et al. Cytokines in Chronic Rhinosinusitis. Role in Eosinophilia and Aspirin-exacerbated Respiratory Disease. Am J Respir Crit Care Med. 2015;192:682–94. - PMC - PubMed
    1. Wang BF, Cao PP, Long XB, Zhang XH, Xu K, Cui YH, et al. Distinct mucosal immunopathologic profiles in atopic and nonatopic chronic rhinosinusitis without nasal polyps in Central China. Int Forum Allergy Rhinol. 2016;6:1013–9. - PubMed
    1. Tomassen P, Vandeplas G, Van Zele T, Cardell LO, Arebro J, Olze H, et al. Inflammatory endotypes of chronic rhinosinusitis based on cluster analysis of biomarkers. J Allergy Clin Immunol. 2016;137:1449–56e4. - PubMed
    1. Weibman AR, Huang JH, Stevens WW, Suh LA, Price CPE, Lidder AK, et al. A prospective analysis evaluating tissue biopsy location and its clinical relevance in chronic rhinosinusitis with nasal polyps. Int Forum Allergy Rhinol. 2017;7:1058–64. - PMC - PubMed

Publication types