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Comment
. 2018 Feb 15;25(2):126-127.
doi: 10.1016/j.chembiol.2018.01.018.

Screening Drugs for Kidney Disease: Targeting the Podocyte

Joshua S Bryer  1 , Katalin Susztak  2
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Comment

Screening Drugs for Kidney Disease: Targeting the Podocyte

Joshua S Bryer et al. Cell Chem Biol. .
Free article

Abstract

Podocytes cover the kidney glomerular basement membrane and present the final barrier in the renal filtration system. Podocyte loss, observed in most kidney diseases, correlates with kidney function decline. In this issue of Cell Chemical Biology, Seiber et al. (2018), using a high-throughput chemical screen, identified the compound CDG-0876, which improved podocyte survival.

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  • GDC-0879, a BRAFV600E Inhibitor, Protects Kidney Podocytes from Death.
    Sieber J, Wieder N, Clark A, Reitberger M, Matan S, Schoenfelder J, Zhang J, Mandinova A, Bittker JA, Gutierrez J, Aygün O, Udeshi N, Carr S, Mundel P, Jehle AW, Greka A. Sieber J, et al. Cell Chem Biol. 2018 Feb 15;25(2):175-184.e4. doi: 10.1016/j.chembiol.2017.11.006. Epub 2017 Dec 14. Cell Chem Biol. 2018. PMID: 29249695 Free PMC article.

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