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Comment
. 2018 Feb 15;69(4):537-538.
doi: 10.1016/j.molcel.2018.01.036.

m6A and eIF2α-ⓟ Team Up to Tackle ATF4 Translation during Stress

Emily Nicole Powers  1 , Gloria Ann Brar  2
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m6A and eIF2α-ⓟ Team Up to Tackle ATF4 Translation during Stress

Emily Nicole Powers et al. Mol Cell. .
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Abstract

While m6A modification of mRNAs is now known to be widespread, the cellular roles of this modification remain largely mysterious. In this issue of Molecular Cell, Zhou et al. (2018) show that m6A modification unexpectedly contributes to the established uORF- and eIF2α-ⓟ-dependent mechanism of ATF4 translational regulation in response to stress.

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