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Review
. 2018 Oct-Nov;20(9-10):512-520.
doi: 10.1016/j.micinf.2018.02.002. Epub 2018 Feb 14.

Diversion of complement-mediated killing by Bordetella

Anaïs Thiriard  1 , Dominique Raze  1 , Camille Locht  2
Affiliations
Free article
Review

Diversion of complement-mediated killing by Bordetella

Anaïs Thiriard et al. Microbes Infect. 2018 Oct-Nov.
Free article

Abstract

The complement cascade participates in protection against bacterial infections, and pathogens, including Bordetella pertussis, have developed complement-evading strategies. Here we discuss current knowledge on B. pertussis complement evasion strategies and the role of antibody-dependent complement-mediated killing in protection against B. pertussis infection pointing out important knowledge gaps for further research to improve current pertussis vaccines.

Keywords: Antibodies; Bordetella; Complement; Pertussis.

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