Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
. 2018 Feb 17;18(1):24.
doi: 10.1186/s12871-018-0479-7.

Comparative study of ultrasound-guided paravertebral block versus intravenous tramadol for postoperative pain control in percutaneous nephrolithotomy

Zehra Hatipoglu  1 , Ersel Gulec  2 , Mediha Turktan  2 , Volkan Izol  3 , Atilla Arıdogan  3 , Yasemin Gunes  2 , Dilek Ozcengiz  2
Affiliations
Randomized Controlled Trial

Comparative study of ultrasound-guided paravertebral block versus intravenous tramadol for postoperative pain control in percutaneous nephrolithotomy

Zehra Hatipoglu et al. BMC Anesthesiol. .

Abstract

Background: Percutaneous nephrolithotomy (PCNL) is a minimally invasive surgical procedure for renal calculi, and nephrostomy tubes lead to postoperative pain after PCNL. Regional techniques (e.g., epidural analgesia and peripheral blocks) and opioids are applied for postoperative pain treatment. The aim of this study was to compare effectiveness of ultrasound-guided paravertebral block (PVB) and tramadol on postoperative pain in patients who underwent PCNL.

Method: Fifty-three patients were included in this prospective randomized study. The patients were allocated into two groups: the PVB group (group P, n = 26) and the tramadol group (group T, n = 27). All patients were administered standard general anaesthesia. Ultrasound-guided PVB was performed at the T11- L1 levels using 0.5% bupivacaine for a total dose of 15 mL in group P. Patients in group T were intravenously administered a loading dose of 1 mg/kg tramadol. Patients in both groups were given patient-controlled analgesia. Haemodynamic parameters, visual analogue scale (VAS) scores, side effects, and complications, tramadol consumption and additional analgesic requirements of the patients were recorded after surgery.

Results: Haemodynamic parameters were statistically similar between the groups. The VAS in group P were statistically lower than in group T. In the 24-h period after surgery, total PCA tramadol consumption was statistically lower in group P than in group T. The use of supplemental analgesic in group T was higher than in group P.

Conclusions: Ultrasound-guided PVB was found to be an effective analgesia compared to tramadol, and no additional complications were encountered.

Trial registration: ClinicalTrials.gov, NCT02412930 , date of registration: March 27, 2015, retrospectively registered.

Keywords: Paravertebral block; Postoperative analgesia; Tramadol.

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent to participate

Ethical approval was obtained from Cukurova University Ethics Committee (5/8, 22.March.2012).

All participants signed a written informed consent before enrolment.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Flow diagram of the study
Fig. 2
Fig. 2
Visual analogue scale scores of the groups over postoperative time
See this image and copyright information in PMC

References

    1. Yuan H, Zheng S, Liu L, Han P, Wang J, Wei Q. The efficacy and safety of tubeless percutaneous nephrolithotomy: a systematic review and meta-analysis. Urol Res. 2011;39:401–410. doi: 10.1007/s00240-010-0355-5. - DOI - PubMed
    1. Aydoğan H, Kucuk A, Yuce HH, Karahan MA, Ciftci H, Gulum M, et al. Adding 75 mg pregabalin to analgesic regimen reduces pain scores and opioid consumption in adults following percutaneous nephrolithotomy. Rev Bras Anestesiol. 2014;64:335–342. doi: 10.1016/j.bjan.2013.08.001. - DOI - PubMed
    1. Parikh GP, Shah VR, Vora KS, Parikh BK, Modi MP, Panchal ARUN. Ultrasound guided peritubal infiltration of 0.25% ropivacaine for postoperative pain relief in percutaneous nephrolithotomy. Middle East J Anaesthesiol. 2013;22:149–154. - PubMed
    1. Ozkan D, Akkaya T, Karakoyunlu N, Arık E, Ergil J, Koc Z, et al. Effect of ultrasound-guided intercostal nerve block on postoperative pain after percutaneous nephrolithotomy: prospective randomized controlled study. Anaesthesist. 2013;62:988–994. doi: 10.1007/s00101-013-2253-z. - DOI - PubMed
    1. Borle AP, Chhabra A, Subramaniam R, Rewari V, Sinha R, Ramachandran R, et al. Analgesic efficacy of paravertebral bupivacaine during percutaneous nephrolithotomy: an observer blinded, randomized controlled trial. J Endourol. 2014;28:1085–1090. doi: 10.1089/end.2014.0179. - DOI - PubMed

Publication types

Associated data

LinkOut - more resources