New ADCY3 Variants Dance in Obesity Etiology

Yan Tian¹, Boqiang Peng², Xianghui Fu³

Affiliations

¹ Division of Endocrinology and Metabolism, State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; These authors contributed equally to this work.
² West China Medical School, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; These authors contributed equally to this work.
³ Division of Endocrinology and Metabolism, State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China. Electronic address: xfu@scu.edu.cn.

PMID: 29454745
DOI: 10.1016/j.tem.2018.02.004

Comment

New ADCY3 Variants Dance in Obesity Etiology

Yan Tian et al. Trends Endocrinol Metab. 2018 Jun.

. 2018 Jun;29(6):361-363.

doi: 10.1016/j.tem.2018.02.004. Epub 2018 Feb 14.

Authors

Yan Tian¹, Boqiang Peng², Xianghui Fu³

Affiliations

¹ Division of Endocrinology and Metabolism, State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; These authors contributed equally to this work.
² West China Medical School, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; These authors contributed equally to this work.
³ Division of Endocrinology and Metabolism, State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China. Electronic address: xfu@scu.edu.cn.

PMID: 29454745
DOI: 10.1016/j.tem.2018.02.004

Abstract

The genetic etiology for obesity-related traits remains elusive. Recent studies link novel ADCY3 variants to obesity and diabetes, and identify an important role of ADCY3-mediated signaling at neuronal primary cilia in the predisposition of obesity. These findings provide new information on obesity etiology and suggest potential anti-obesity therapeutic strategies.

Keywords: ADCY3; MC4R; cAMP; diabetes; genetic mutations; obesity.

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Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity.
Siljee JE, Wang Y, Bernard AA, Ersoy BA, Zhang S, Marley A, Von Zastrow M, Reiter JF, Vaisse C. Siljee JE, et al. Nat Genet. 2018 Feb;50(2):180-185. doi: 10.1038/s41588-017-0020-9. Epub 2018 Jan 8. Nat Genet. 2018. PMID: 29311635 Free PMC article.
Loss-of-function variants in ADCY3 increase risk of obesity and type 2 diabetes.
Grarup N, Moltke I, Andersen MK, Dalby M, Vitting-Seerup K, Kern T, Mahendran Y, Jørsboe E, Larsen CVL, Dahl-Petersen IK, Gilly A, Suveges D, Dedoussis G, Zeggini E, Pedersen O, Andersson R, Bjerregaard P, Jørgensen ME, Albrechtsen A, Hansen T. Grarup N, et al. Nat Genet. 2018 Feb;50(2):172-174. doi: 10.1038/s41588-017-0022-7. Epub 2018 Jan 8. Nat Genet. 2018. PMID: 29311636 Free PMC article.
Loss-of-function mutations in ADCY3 cause monogenic severe obesity.
Saeed S, Bonnefond A, Tamanini F, Mirza MU, Manzoor J, Janjua QM, Din SM, Gaitan J, Milochau A, Durand E, Vaillant E, Haseeb A, De Graeve F, Rabearivelo I, Sand O, Queniat G, Boutry R, Schott DA, Ayesha H, Ali M, Khan WI, Butt TA, Rinne T, Stumpel C, Abderrahmani A, Lang J, Arslan M, Froguel P. Saeed S, et al. Nat Genet. 2018 Feb;50(2):175-179. doi: 10.1038/s41588-017-0023-6. Epub 2018 Jan 8. Nat Genet. 2018. PMID: 29311637

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New ADCY3 Variants Dance in Obesity Etiology

Affiliations

New ADCY3 Variants Dance in Obesity Etiology

Authors

Affiliations

Abstract

Comment on

Publication types

MeSH terms