Editorial

. 2018 Dec;11(12):1834-1836.

doi: 10.1016/j.jcmg.2017.12.009. Epub 2018 Feb 14.

Radiolabeled Duramycin: Promising Translational Imaging of Myocardial Apoptosis

Joseph C Wu¹, Xulei Qin², Evgenios Neofytou²

Affiliations

¹ Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, California; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California; Department of Radiology, Stanford University School of Medicine, Stanford, California. Electronic address: joewu@stanford.edu.
² Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, California; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California.

PMID: 29454760
PMCID: PMC6383561
DOI: 10.1016/j.jcmg.2017.12.009

Editorial

Radiolabeled Duramycin: Promising Translational Imaging of Myocardial Apoptosis

Joseph C Wu et al. JACC Cardiovasc Imaging. 2018 Dec.

. 2018 Dec;11(12):1834-1836.

doi: 10.1016/j.jcmg.2017.12.009. Epub 2018 Feb 14.

Authors

Joseph C Wu¹, Xulei Qin², Evgenios Neofytou²

Affiliations

¹ Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, California; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California; Department of Radiology, Stanford University School of Medicine, Stanford, California. Electronic address: joewu@stanford.edu.
² Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, California; Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California.

PMID: 29454760
PMCID: PMC6383561
DOI: 10.1016/j.jcmg.2017.12.009

No abstract available

Keywords: duramycin; myocardial apoptosis; radionuclide imaging.

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Figures

**Figure 1.. Central pathways and imaging targets for apoptosis.**
Both extrinsic pathway (cell-surface receptors) and intrinsic pathway (mitochondria) activate caspase-3 to finally result in apoptosis. The externalized phospholipid (i.e., PS and PE), activated caspase-3, and dissipated Δψ_m can be targeted by various radiotracers for noninvasive imaging of apoptosis. PS: phosphatidylserine; PE: phosphatidylethanolamine; Δψ_m: mitochondrial transmembrane potential.

See this image and copyright information in PMC

Comment on

Molecular Imaging of Apoptosis in Ischemia Reperfusion Injury With Radiolabeled Duramycin Targeting Phosphatidylethanolamine: Effective Target Uptake and Reduced Nontarget Organ Radiation Burden.
Kawai H, Chaudhry F, Shekhar A, Petrov A, Nakahara T, Tanimoto T, Kim D, Chen J, Lebeche D, Blankenberg FG, Pak KY, Kolodgie FD, Virmani R, Sengupta P, Narula N, Hajjar RJ, Strauss HW, Narula J. Kawai H, et al. JACC Cardiovasc Imaging. 2018 Dec;11(12):1823-1833. doi: 10.1016/j.jcmg.2017.11.037. Epub 2018 Feb 14. JACC Cardiovasc Imaging. 2018. PMID: 29454770

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References

1. Cardiovascular diseases fact sheet. World Health Organization 2017, Available from: http://www.who.int/mediacentre/factsheets/fs317/en/
1. Hausenloy DJ, Yellon DM. Myocardial ischemia-reperfusion injury: a neglected therapeutic target. J Clin Invest 2013;123:92–100. - PMC - PubMed
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Radiolabeled Duramycin: Promising Translational Imaging of Myocardial Apoptosis

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