Evaluation of α-glucosidase inhibiting potentials with docking calculations of synthesized arylidene-pyrazolones

Abstract

Herein, condensation of aryl(hetaryl)pyrazole-4-carbaldehydes 1(a-c) with substituted pyrazolones 2(a-d) lead to the corresponding arylidene-pyrazolones 3(a-l) which were tested against α-glucosidase enzyme. The synthesized compounds displayed moderate to good activity. Among these, a coumarin derivative 3k exhibited excellent results (IC₅₀ 2.10 ± 0.004 µM) in comparison to clinical drug acarbose (IC₅₀ 37.38 ± 0.12 µM). The ligand-protein interactions were identified through docking and stabilizing energy calculations.

Keywords: Antipyrine; Arylidenes; Coumarins; Enzyme Inhibitor; Knoevenagel condensations.