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. 2018 Mar 1;28(5):841-846.
doi: 10.1016/j.bmcl.2018.02.013. Epub 2018 Feb 8.

Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes

Michael P Winters  1 , Zhihua Sui  2 , Mark Wall  2 , Yuanping Wang  2 , Joseph Gunnet  2 , James Leonard  2 , Hong Hua  2 , Wen Yan  2 , Arthur Suckow  2 , Austin Bell  2 , Wilmelenne Clapper  2 , Celia Jenkinson  2 , Peter Haug  2 , Tatiana Koudriakova  2 , Norman Huebert  2 , William V Murray  2
Affiliations

Discovery of N-arylpyrroles as agonists of GPR120 for the treatment of type II diabetes

Michael P Winters et al. Bioorg Med Chem Lett. .

Erratum in

Abstract

The discovery of a novel series of N-arylpyrroles as agonists of GPR120 (FFAR4) is discussed. One lead compound is a potent GPR120 agonist, has good selectivity for related receptor GPR40 (FFAR1), has acceptable PK properties, and is active in 2 models of Type 2 Diabetes in mice.

Keywords: DIO mouse; FFAR4; GPR120; GPR40; N-arylpyrrole; Type 2 diabetes; oGTT.

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