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. 2017 Jul-Aug;21(4):276-284.
doi: 10.4103/jisp.jisp_278_17.

Correlative analysis of plasma and urine neopterin levels in the pre- and post-menopausal women with periodontitis, following nonsurgical periodontal therapy

Jammula Surya Prasanna  1 , Chinta Sumadhura  1 , Parupalli Karunakar  2 , Koduganti Rekharani  1 , Gireddy Himabindu  1 , Ambati Manasa  1
Affiliations

Correlative analysis of plasma and urine neopterin levels in the pre- and post-menopausal women with periodontitis, following nonsurgical periodontal therapy

Jammula Surya Prasanna et al. J Indian Soc Periodontol. 2017 Jul-Aug.

Abstract

Context: Periodontitis is an inflammatory condition which is distinguished by the devastation of the supported tooth structures. In such inflammatory conditions, some biomarkers such as neopterin will be secreted and elevated in the body fluids, which can be used as a diagnostic marker for the present and future disease activity.

Aims: Assessment of the neopterin as a biomarker in inflammatory conditions such as menopause and periodontitis.

Settings and design: A cross-sectional interventional study.

Materials and methods: Sixty female individuals with a mean age of 40-60 years with chronic periodontitis were included in this study. All were categorized into two groups of thirty each, depending on their menstrual history: Group I - thirty premenopausal women and Group II - thirty postmenopausal women. Urine and plasma were collected from both groups to estimate neopterin levels. ELISA kit was used to assess the neopterin levels at baseline and after 3 months of nonsurgical periodontal therapy (NSPT).

Statistical analysis used: IBM SPSS version 21 software.

Results: A significant depreciation in the mean values of all the parameters from baseline to 3 months (P < 0.001), in the intragroup analysis, was observed. Plasma (0.006) and urine (0.004) reduction was seen.

Conclusions: In both the groups, in 3 months after NSPT, decreased neopterin levels were found, suggesting that the NSPT is the definitive therapy. Further, suggesting that, neopterin levels in the plasma and urine can be used as an index to identify the periodontal inflammation and destruction.

Keywords: Menopause; neopterin; nonsurgical periodontal therapy; periodontitis; scaling and root planing.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Flowchart 1
Flowchart 1
Consort flowchart – patient selection criteria
Figure 1
Figure 1
(a) Comparison of plasma and urine neopterin in premenopausal group. (b) Urine neopterin levels in both the groups at baseline and 3 months
Figure 2
Figure 2
(a) Comparison of plasma and urine neopterin in postmenopausal group. (b) Comparison of plasma neopterin in both the groups at baseline and 3 months
Figure 3
Figure 3
Comparison of plasma and urine neopterin in both menopausal groups
See this image and copyright information in PMC

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