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. 2018 Jan-Jun;9(1):42-46.
doi: 10.4103/jnsbm.JNSBM_79_17.

Chest X-Ray Findings Comparison between Multi-drug-resistant Tuberculosis and Drug-sensitive Tuberculosis

Aziza Ghanie Icksan  1 , Martin Raja Sonang Napitupulu  1 , Mohamad Arifin Nawas  2 , Fariz Nurwidya  2
Affiliations

Chest X-Ray Findings Comparison between Multi-drug-resistant Tuberculosis and Drug-sensitive Tuberculosis

Aziza Ghanie Icksan et al. J Nat Sci Biol Med. 2018 Jan-Jun.

Abstract

Background: Imaging has a big role in tuberculosis (TB) diagnosis and chest X-ray is preferable because it is available in primary health care and can point out the location, area, and morphology of lesions, such as cavity, consolidation, pleural effusions, and fibrosis. We aimed to compare the chest X-ray findings in multi-drug resistant TB (MDR-TB) and in drug-sensitive TB (DS-TB) cases.

Methods: This is a retrospective cross-sectional study which compares chest X-ray findings of two groups of patients, involving 183 DS-TB patients and 183 MDR-TB patients. Radiologic findings that we analyzed were infiltrate, consolidation, cavity, ground glass opacity, fibrosis, bronchiectasis, calcification, node, atelectasis, bullae, emphysema, and other nonlung parenchymal findings.

Results: MDR-TB group have 177 (96%) patients with large lesions, 6 (4%) with medium lesions, and no small lesions. DS-TB group have 55 (30%) patients with small lesions, 78 (43%) with medium lesions, and 50 (27%) with large lesions. Active TB lesions in the forms of infiltrate and ground-glass opacity were more dominant in DS-TB group, whereas consolidation, cavity, fibrosis, bronchiectasis, calcification, node, atelectasis, bullae, emphysema, and other nonlung parenchymal findings, were more dominant in MDR-TB.

Conclusions: There were significant differences in chest X-ray findings between MDR-TB and DS-TB in terms of lesion size and morphology. Recognition of chest X-ray findings could help the physician to differentiate patient with suspected MDR-TB.

Keywords: Chest X-ray; drug-sensitive tuberculosis; multi-drug resistant tuberculosis.

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Conflict of interest statement

There are no conflicts of interest.

References

    1. World Health Organization. Global Tuberculosis Report 2014. USA: World Health Organization; 2014. pp. 1–147.
    1. Center for Tuberculosis Information and Data. Ministry of Health Indonesia. 2015
    1. Icksan AG, Maryastuti M. Characteristics of chest X-ray lesion in smear-negative TB patient with culture-positive vs. culture-negative in the Persahabatan Hospital, Jakarta. Bul Ilmiah Radiol. 2012;2:80–90. [Indonesian Society of Radiology chapter Yogyakarta and Department of Radiology, University of Gajah Mada Faculty of Medicine, Yogyakarta]
    1. Icksan AG. Doctoral Dissertation of the PhD in Clinical Medicine. Yogyakarta: University of Gajah Mada Faculty of Medicine; 2014. The Accuracy of CT Scan without Contrast Scoring System in the Diagnosis of Adult Pulmonary TB; pp. 1–156.
    1. Technical Guidelines for Multi-drug Resistant Tuberculosis Holistic Control. Directorate General for Disease and Environmental Health Control. Jakarta: Ministry of Health Indonesia; 2014. Technical Guidelines for Multi-drug Resistant Tuberculosis Holistic Control; pp. 1–111.

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