Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2018 Feb 14;24(6):763-766.
doi: 10.3748/wjg.v24.i6.763.

Gastroenteritis in an adult female revealing hemolytic uremic syndrome: Case report

Paulina Chinchilla-López  1 , Vania Cruz-Ramón  2 , Oscar Ramírez-Pérez  2 , Nahum Méndez-Sánchez  2
Affiliations
Case Reports

Gastroenteritis in an adult female revealing hemolytic uremic syndrome: Case report

Paulina Chinchilla-López et al. World J Gastroenterol. .

Abstract

Nowadays acute gastroenteritis infection caused by Escherichia coli (E. coli) O157:H7 is frequently associated with hemolytic uremic syndrome (HUS), which usually developed after prodromal diarrhea that is often bloody. The abdominal pain accompanied by failure kidney is a suspicious symptom to develop this disorder. Their pathological characteristic is vascular damage which manifested as arteriolar and capillary thrombosis with abnormalities in the endothelium and vessel walls. The major etiological agent of HUS is enterohemorragic (E coli) strain belonging to serotype O157:H7. The lack of papers about HUS associated to gastroenteritis lead us to report this case for explain the symptoms that are uncommon. Furthermore, this report provides some strategies to suspect and make an early diagnosis, besides treatment approach to improving outcomes and prognosis for patients with this disorder.

Keywords: Escherichia coli O157; Gastroenteritis; Gastrointestinal hemorrhage; Hemolytic-uremic syndrome; Shiga-toxigenic Escherichia coli.

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest statement: All authors have no conflicts of interests to declare.

Figures

Figure 1
Figure 1
Tridimensional structure of Shiga toxin. Shiga toxins are a family of related toxins with two major groups, Stx1 and Stx2, expressed by genes considered to be part of the genome of lambdoidprophages. The most common sources for Shiga toxin are the bacteria S. dysenteriae and the shigatoxigenic serotypes of Escherichia coli, which includes serotypes O157:H7, O104:H4, and other enterohemorrhagic E. coli.
See this image and copyright information in PMC

References

    1. Furlan M, Lämmle B. Haemolytic-uraemic syndrome and thrombotic thrombocytopenic purpura--new insights into underlying biochemical mechanisms. Nephrol Dial Transplant. 2000;15:1112–1114. - PubMed
    1. Igarashi T, Ito S, Sako M, Saitoh A, Hataya H, Mizuguchi M, Morishima T, Ohnishi K, Kawamura N, Kitayama H, et al. Guidelines for the management and investigation of hemolytic uremic syndrome. Clin Exp Nephrol. 2014;18:525–557. - PubMed
    1. Blombery P, Scully M. Management of thrombotic thrombocytopenic purpura: current perspectives. J Blood Med. 2014;5:15–23. - PMC - PubMed
    1. Karpac CA, Li X, Terrell DR, Kremer Hovinga JA, Lämmle B, Vesely SK, George JN. Sporadic bloody diarrhoea-associated thrombotic thrombocytopenic purpura-haemolytic uraemic syndrome: an adult and paediatric comparison. Br J Haematol. 2008;141:696–707. - PubMed
    1. Holtz LR, Neill MA, Tarr PI. Acute bloody diarrhea: a medical emergency for patients of all ages. Gastroenterology. 2009;136:1887–1898. - PubMed

Publication types

MeSH terms

Substances