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. 2017 Dec;12(6):396-400.
doi: 10.1159/000479862. Epub 2017 Dec 13.

Electron Beam Intraoperative Radiotherapy (ELIOT) in Pregnant Women with Breast Cancer: From in Vivo Dosimetry to Clinical Practice

Maria Leonardi  1 , Agnese Cecconi  2   3 , Rosa Luraschi  4 , Elena Rondi  4 , Federica Cattani  4 , Roberta Lazzari  1 , Anna Morra  1 , Santos Soto  5 , Vanna Zanagnolo  6 , Viviana Galimberti  7 , Oreste Gentilini  7   8 , Fedro Peccatori  9 , Barbara Jereczek-Fossa  1   3 , Roberto Orecchia  2   3   10
Affiliations

Electron Beam Intraoperative Radiotherapy (ELIOT) in Pregnant Women with Breast Cancer: From in Vivo Dosimetry to Clinical Practice

Maria Leonardi et al. Breast Care (Basel). 2017 Dec.

Abstract

Background: The aim of this study was to confirm our preliminary results with in vivo dosimetry in non-pregnant breast cancer patients receiving electron beam intraoperative radiotherapy (ELIOT) and to report on the first treatment in a pregnant woman.

Patients and methods: Following our previous experience, 5 non-pregnant patients receiving ELIOT to the tumor bed after breast-conserving surgery (BCS) were studied with thermoluminescent dosimeters positioned in the subdiaphragmatic region, within the uterus, and in the ovarian region. In December 2011, the first pregnant breast cancer patient underwent BCS and ELIOT (21 Gy at 90% isodose) during the 15th week of gestation.

Results: The mean dose to the subdiaphragmatic external region in the 5 non-pregnant patients was 5.57 mGy, while pelvic measurements were below 1 mGy. The actual dosimetry of the pregnant patient showed a mean subdiaphragmatic dose of 4.34 mGy, a mean suprapubic dose of 1.64 mGy, and mean ovarian doses of 1.48 mGy (right-sided) and 1.44 mGy (left-sided). The expected dose to the fetus was estimated as 0.84 mGy (0.004% of the prescribed dose).

Conclusion: ELIOT as an anticipated boost to the breast could be considered in pregnant women in the early second trimester, postponing whole-breast irradiation after delivery.

Keywords: Breast cancer; Pregnancy; Radiation therapy.

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