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Case Reports
. 2018 Feb 14:7:22.
doi: 10.1186/s13756-018-0313-5. eCollection 2018.

Successful treatment of extensively drug-resistant Acinetobacter baumannii ventriculitis with polymyxin B and tigecycline- a case report

Wei Guo  1 , Shao-Chun Guo  1 , Min Li  1 , Li-Hong Li  1 , Yan Qu  1
Affiliations
Case Reports

Successful treatment of extensively drug-resistant Acinetobacter baumannii ventriculitis with polymyxin B and tigecycline- a case report

Wei Guo et al. Antimicrob Resist Infect Control. .

Abstract

Background: Acinetobacter baumannii nosocomial ventriculitis/meningitis, especially those due to drug-resistant strains, has substantially increased over recent years. However, limited therapeutic options exist for the Acinetobacter baumannii ventriculitis/meningitis because of the poor penetration rate of most antibiotics through the blood-brain barrier.

Case presentation: A 57-year-old male patient developed ventriculitis from an extensively drug-resistant strain of Acinetobacter baumannii after the decompressive craniectomy for severe traumatic brain injury. The patient was successfully treated with intraventricular and intravenous polymyxin B together with intravenous tigecycline.

Conclusions: The case illustrates intraventricular polymyxin B can be a therapeutic option against extensively drug-resistant Acinetobacter baumannii ventriculitis.

Keywords: Acinetobacter Baumannii; Intraventricular therapy; Multidrug resistance; Polymyxin B; Ventriculitis.

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Conflict of interest statement

The study was approved by the Ethics Committee of Tangdu Hospital, Shaanxi, China.Written informed consent was obtained from the next of kin of the patient for publication of this Case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Transient ventricular adhesion due to intraventricular (IVT) polymyxin B administration observed from CT scan. a CT scan obtained on day 1 of the hospitalization, showing bilateral hydrocephalus. b On day 6 of the hospitalization, CT scan showing the contractible right ventricle and enlarged left ventricle after IVT polymyxin B administration through right EVD (arrows). c On day 11 of the hospitalization, CT scan showing the contractible right ventricle and enlarged left ventricle after IVT polymyxin B administration through right EVD (arrows). d On day 18 of the hospitalization, CT scan showing the contractible left ventricle after IVT polymyxin B administration through left EVD (arrows). e CT scan obtained on day 20 of the hospitalization. f CT scan obtained on day 23 of the hospitalization
See this image and copyright information in PMC

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