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. 2018 Jan 22:7:1.
doi: 10.4103/2277-9175.223735. eCollection 2018.

The Effect of Levothyroxine and Selenium versus Levothyroxine Alone on Reducing the Level of Anti-thyroid Peroxidase Antibody in Autoimmune Hypothyroid Patients

Ali Kachouei  1 , Hassan Rezvanian  1 , Masoud Amini  1 , Ashraf Aminorroaya  1 , Eshagh Moradi  2
Affiliations

The Effect of Levothyroxine and Selenium versus Levothyroxine Alone on Reducing the Level of Anti-thyroid Peroxidase Antibody in Autoimmune Hypothyroid Patients

Ali Kachouei et al. Adv Biomed Res. .

Abstract

Background: Due to the prevalence of autoimmune hypothyroidism and its effects on physical and mental health it is necessary to provide a treatment which is also effective in preventing the progression of sub-clinical hypothyroidism in these patients. This study aims to investigate the effect of selenium supplementation on of anti-thyroid hormone antibodies in these patients.

Materials and methods: In a randomized clinical trial, 70 patients with autoimmune hypothyroidism randomly divided into two groups of 35 each, the first group was treated with oral selenium treatment with levothyroxine (LT4) and to the second group along with LT4, placebo was also prescribed. Serum selenium level, thyroid hormones and anti-thyroid hormone antibodies before and after 3 months of treatment in both groups, were determined, and the results were analyzed using SPSS software.

Results: The mean of the serum anti-thyroid peroxidase serum level in the intervention group before and after treatment was 682.18 ± 87.25 and 522.96 ± 47.21 and the difference before and after treatment was statistically significant (P = 0.021). The level of this antibody before and after treatment in the control group was 441 ± 53.54 and 501.18 ± 77.68, and no significant differences between two groups were observed before and after treatment (P = 0.42).

Conclusion: Selenium supplementation may help to reduce the levels of antibodies in patients with autoimmune hypothyroidism.

Keywords: Anti-thyroid hormone antibodies; autoimmune hypothyroidism; selenium.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Consort flow diagram
Figure 2
Figure 2
Mean changes of anti-thyroid peroxidase between the two groups (P = 0.12)
Figure 3
Figure 3
Mean changes of anti-thyroglobulin between the two groups (P = 0.98)
Figure 4
Figure 4
Mean changes of thyroid stimulating hormone between the two groups (P = 0.93)
Figure 5
Figure 5
Mean changes of FT4 between the two groups (P = 0.41)
Figure 6
Figure 6
Mean changes of FT3 between the two groups (P = 0.21)
Figure 7
Figure 7
Mean changes of selenium level between the two groups (P = 0.003)
See this image and copyright information in PMC

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