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. 2018 Jan 30:7:8.
doi: 10.4103/abr.abr_141_17. eCollection 2018.

Quercetin Prevents Body Weight Loss Due to the Using of Superparamagnetic Iron Oxide Nanoparticles in Rat

Rezvan Enteshari Najafabadi  1 , Nasrin Kazemipour  1 , Abolghasem Esmaeili  2 , Siamak Beheshti  3 , Saeed Nazifi  4
Affiliations

Quercetin Prevents Body Weight Loss Due to the Using of Superparamagnetic Iron Oxide Nanoparticles in Rat

Rezvan Enteshari Najafabadi et al. Adv Biomed Res. .

Abstract

Background: Superparamagnetic iron oxide nanoparticles (SPION) have been largely considered for numerous applications in biomedicine such as magnetic resonance imaging, hyperthermia, cell tracking, anticancer treatment, and targeted delivery of drugs or genes. However, they may have side effects such body weight loss. Quercetin (QT), a strong antioxidant and free radical scavenger and a natural flavonoid, has a wide range of biological and therapeutic effects. In this study, the effect of QT on prevention of weight loss due to the using of SPION has been investigated.

Materials and methods: SPION and QT-SPION were administered orally at 50 and 100 mg/kg for 7 days. Then, the body weight was measured at the beginning and the end of the study.

Results: Rats fed with 50 and 100 mg/kg SPION showed a significant weight loss, whereas those that fed with 50 mg/kg QT-SPION did not. A weight loss was observed in rats treated with 100 mg/kg of QT-SPION.

Conclusions: The results of this study showed that quercetin could prevent weight loss due to the SPION.

Keywords: Nanoparticles; quercetin; superparamagnetic iron oxide; weight loss.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Bodyweight change of Wistar rats at day 1 and 7 of the experiment. (a) control group did not receive anything, (b) sham group received only deionized water, (c-f) rats in these groups treated with Fe3O4 at a dose of (c) 50, (d) 100 mg/kg, and quercetin conjugated Fe3O4 nanoparticles at a dose of (e) 50, (f) 100 mg/kg. All values reported are mean ± standard error mean (n = 6). (* for P < 0.05, ** for P < 0.01, and *** for P < 0.001). QT: Quercetin
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