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. 2018 Jan 30:7:16.
doi: 10.4103/abr.abr_225_16. eCollection 2018.

Effects of Streptokinase and Normal Saline on the Incidence of Intra-abdominal Adhesion 1 Week and 1 Month after Laparotomy in Rats

Ali Hosseini  1 , Sima Akhavan  2 , Maziar Menshaei  3 , Awat Feizi  4
Affiliations

Effects of Streptokinase and Normal Saline on the Incidence of Intra-abdominal Adhesion 1 Week and 1 Month after Laparotomy in Rats

Ali Hosseini et al. Adv Biomed Res. .

Abstract

Background: Intra-abdominal adhesions after surgery are usually in the form of bands and can annoy the patient throughout life causing repeated surgical procedures. Therefore, any action to prevent adhesions after surgery can increase longevity and quality of life. For this aim, this study investigates the effect of streptokinase and normal saline on the 7th day and 1 month after laparotomy.

Materials and methods: Experimental study was conducted on thirty healthy male Wistar rats weighing 200-250 g with age of 3 months divided into three groups of 10. Group I: No treatment, Group II: Received normal saline, and Group III: Received normal saline and streptokinase at the same time. One week and 1 month after laparotomy, the frequency of the presence or absence of adhesion bands was performed by a person who was unaware of the sample grouping. The collected information was analyzed with the SPSS software (version 16; SPSS Inc., Chicago, IL, USA).

Results: Adhesion frequency was found to be 20% on the 7th day (early) and 1 month after laparotomy (late) for Group 1, and it was 40% on early and late for Group II, while 0% on the early and late for Group III. Hence, in the group receiving streptokinase, no early or late adhesion was observed; therefore, it had a significant role in the prevention of intra-abdominal adhesions (P < 0.05). However, adhesions in the group receiving normal saline had no remarkable difference with the group receiving no drug (P > 0.05).

Conclusion: According to the results of our study, we believe that streptokinase could be a good antiadhesive agent considering its effectiveness.

Keywords: Intra-abdominal adhesion; normal saline; streptokinase.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Grading adhesions in the abdominal cavity; Grade I had only one adhesive band, Grade II had II-III adhesive bands, and Grade III had adhesion to the wall
Figure 2
Figure 2
Grade of adhesions in the 7th day and 1 month after laparotomy in three groups
Figure 3
Figure 3
Images of scars and hair growth in Groups II and III. A1: the scar condition and A2: hair growth in rats receiving normal saline. B1: The scar condition and B2: Hair growth in rats receiving normal saline with streptokinase
See this image and copyright information in PMC

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