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. 2018 Jan;4(1):25-28.
doi: 10.1159/000477742. Epub 2017 Jul 6.

Acneiform Rash Caused by an Unlikely Drug: Topiramate

Yesenia Bello-Hernández  1 , Jessica Espinoza-Hernández  2 , Gabriela Moreno-Coutiño  1
Affiliations

Acneiform Rash Caused by an Unlikely Drug: Topiramate

Yesenia Bello-Hernández et al. Skin Appendage Disord. 2018 Jan.

Abstract

Topiramate is an antiepileptic drug that can also be used for migraine prophylaxis, weight control, and even for methamphetamine dependence; the dosage margin is wide, and the list of side effects is shorter than with other anticonvulsants. We present the case of a 35-year-old man with a disseminated rash of the trunk and extremities after treatment with 25 mg of topiramate daily as a prophylactic migraine treatment. This case report is useful, as this patient was not polymedicated and had a score of 7 on the Naranjo Adverse Drug Reaction Probability Scale. The patient was diagnosed as atypical DRESS syndrome and resolved satisfactorily with symptomatic treatment and topiramate withdrawal; slowly, the lesions regressed. He required no further drugs for the dermatologic condition.

Keywords: Adverse event; Migraine; Rash; Topiramate.

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Figures

Fig. 1
Fig. 1
Maculopapular rash.
Fig. 2
Fig. 2
Close-up of maculopapular rash.
See this image and copyright information in PMC

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