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. 2018 Apr;146(5):656-662.
doi: 10.1017/S0950268818000249. Epub 2018 Feb 20.

Epidemiology and control measures of an OXA-48-producing Enterobacteriaceae hospital-wide oligoclonal outbreak

V Pérez-Blanco  1 , L Redondo-Bravo  1 , G Ruíz-Carrascoso  2 , J R Paño-Pardo  3 , R Gómez-Gil  2 , A Robustillo-Rodela  1 , J García-Rodríguez  2 , J Mingorance  2 , R Herruzo  1
Affiliations

Epidemiology and control measures of an OXA-48-producing Enterobacteriaceae hospital-wide oligoclonal outbreak

V Pérez-Blanco et al. Epidemiol Infect. 2018 Apr.

Abstract

The main objective of our study was to describe the epidemiological and microbiological features of an oligoclonal hospital-wide outbreak caused by OXA-48-producing Enterobacteriaceae (OXA-48-PE). OXA-48 is a carbapenemase belonging to Ambler class D beta-lactamases, identified frequently in the Mediterranean and Southern European countries, and associated with several Enterobacteriaceae species. An outbreak of OXA-48-PE with a complex epidemic pattern was detected in January 2011. Initial control measures included contact precautions and the reinforcement of infection control practices, but despite all efforts made, the epidemiological situation hardly changed and new measures were implemented during 2013. An observational retrospective study was performed to describe the main features of the outbreak and to analyse the cumulative incidence (CI) trends. Eight hundred and 16 patients colonised or infected by OXA-48-PE were identified during the 2-year period (January 2013-December 2014), female 46%, mean age (s.d.), 71.6 (15.2). The samples isolated in the incident cases were rectal swabs (80%), urine samples (10.7%), blood samples (2.8%) and other clinical samples (6.6%). The most frequent OXA-48-PE was Klebsiella pneumoniae. Eleven different clones were identified, but K. pneumoniae sequence types 11 and 405 were predominant: ST11 (64.2%) and ST405 (29.3%). OXA-48-PE CI trend suffered a statistically significant change in August 2013, which continued the following months. Though we could not eradicate the outbreak, we observed a statistically significant drop in CI after an intervention for OXA-48-PE control, based on patient cohort, active surveillance, electronic alerts and reinforcement of infection control measures in a tertiary hospital.

Keywords: Carbapenem-resistant Enterobacteriaceae; control measures; epidemiology; outbreak.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Fig. 1.
Fig. 1.
Epidemic curve of new cases per month of OXA-48-PE according to the origin of sample (a) and according to ward of the patient (b).
Fig. 2.
Fig. 2.
Microorganisms isolated in the first sample with an OXA-48-PE.
Fig. 3.
Fig. 3.
Joinpoint Trend of Cumulative Incidence of OXA-48-PE from January 2013 to July 2015.
See this image and copyright information in PMC

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MeSH terms