Loving the poison: the methylcitrate cycle and bacterial pathogenesis

Abstract

Propionate is an abundant catabolite in nature and represents a rich potential source of carbon for the organisms that can utilize it. However, propionate and propionate-derived catabolites are also toxic to cells, so propionate catabolism can alternatively be viewed as a detoxification mechanism. In this review, we summarize recent progress made in understanding how prokaryotes catabolize propionic acid, how these pathways are regulated and how they might be exploited to develop novel antibacterial interventions.

Keywords: Methylcitrate cycle; antimicrobial target; bacterial pathogenesis; propionate metabolism; prp operon; short chain fatty acids.