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Review
. 2018 Apr;32(2):213-221.
doi: 10.1016/j.hoc.2017.11.009. Epub 2017 Dec 29.

Ineffective Erythropoiesis: Anemia and Iron Overload

Ritama Gupta  1 , Khaled M Musallam  2 , Ali T Taher  3 , Stefano Rivella  4
Affiliations
Review

Ineffective Erythropoiesis: Anemia and Iron Overload

Ritama Gupta et al. Hematol Oncol Clin North Am. 2018 Apr.

Abstract

Stress erythropoiesis (SE) is characterized by an imbalance in erythroid proliferation and differentiation under increased demands of erythrocyte generation and tissue oxygenation. β-thalassemia represents a chronic state of SE, called ineffective erythropoiesis (IE), exhibiting an expansion of erythroid-progenitor pool and deposition of alpha chains on erythrocyte membranes, causing cell death and anemia. Concurrently, there is a decrease in hepcidin expression and a subsequent state of iron overload. There are substantial investigative efforts to target increased iron absorption under IE. There are also avenues for targeting cell contact and signaling within erythroblastic islands under SE, for therapeutic benefits.

Keywords: Erythroblastic island; Hepcidin and iron homeostasis; Iron overload; Stress and ineffective erythropoiesis.

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Conflict of interest statement

Conflict of Interest statement

K.M. received honoraria from Novartis, Celgene, and CRISPR Therapeutics. A.T. received research support and honoraria from Novartis, research support from Celgene and Roche.. S.R. is a member of scientific advisory board of Ionis Pharmaceuticals. S.R. is sponsored by Ionis Pharmaceuticals. A.G. declares no conflict of interest.

Figures

Figure 1
Figure 1
Ineffective erythropoiesis and its therapeutic targeting.
See this image and copyright information in PMC

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