Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Apr;32(2):223-236.
doi: 10.1016/j.hoc.2017.11.005. Epub 2017 Dec 28.

Clinical Complications and Their Management

Alessia Marcon  1 , Irene Motta  2 , Ali T Taher  3 , Maria Domenica Cappellini  4
Affiliations
Review

Clinical Complications and Their Management

Alessia Marcon et al. Hematol Oncol Clin North Am. 2018 Apr.

Abstract

The hallmarks of thalassemias are ineffective erythropoiesis and peripheral hemolysis leading to a cascade of events responsible for several clinical complications. This pathophysiologic mechanism can be partially controlled by blood transfusions or by correction of the severity of ineffective erythropoiesis. Thalassemias include a spectrum of phenotypes. Two main groups can be clinically distinguished: transfusion-dependent (TDT) and non-transfusion-dependent (NTDT) thalassemia. Both conditions are characterized by several clinical complications along life; some are shared, whereas some have higher prevalence in one group over the other. The authors present the most common clinical complications in TDT and NTDT and their management.

Keywords: Endocrinopathies; Heart failure; Ineffective erythropoiesis; Iron overload; Liver disease; Thalassemia.

PubMed Disclaimer

MeSH terms