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Review
. 2018 Feb:122:10-20.
doi: 10.1016/j.critrevonc.2017.12.009. Epub 2017 Dec 14.

Systemic treatment in adult uterine sarcomas

I M E Desar  1 , P B Ottevanger  1 , C Benson  2 , W T A van der Graaf  3
Affiliations
Free article
Review

Systemic treatment in adult uterine sarcomas

I M E Desar et al. Crit Rev Oncol Hematol. 2018 Feb.
Free article

Abstract

Uterine sarcomas (US) are rare mesenchymal tumours of the uterus and are divided mainly into uterine leiomyosarcoma (uLMS), low grade endometrial stromal sarcoma (LG-ESS), high grade endometrial stromal sarcoma (HG-ESS), adenosarcomas and high grade undifferentiated sarcoma (HGUS). US are often high-grade tumours with a high local recurrence rate and metastatic risk. We here discuss the current standard of care and knowledge of systemic therapy for adult uterine sarcomas, in particular uLMS, LG-ESS, HG-ESS and HGUS, in both the adjuvant as well as the metastatic setting.

Keywords: Chemotherapy; Hormone therapy; Systemic treatment; Targeted therapy; Uterine sarcoma.

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