Physical activity reduces fatigue in patients with cancer and hematopoietic stem cell transplant recipients: A systematic review and meta-analysis of randomized trials

Affiliations

¹ Pediatric Oncology Group of Ontario, Toronto, ON, Canada.
² Department of Pediatric Psychology, Children's Hospital, London Health Sciences Centre, London, ON, Canada.
³ Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada.
⁴ Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada.
⁵ Centre for Outcomes and Experiences Research in Children's Health, Illness, and Disability, Great Ormond Street Hospital for Children NHS Foundation Trust, London, School of Health Sciences, University of Surrey, Guildford, UK.
⁶ University Hospital Essen, Center for Child and Adolescent Medicine, Department of Pediatric Hematology/Oncology, Essen, Germany.
⁷ Department of Nursing Science, Professional Practice, and Quality, Children's National Health System, WA, District of Columbia, USA; Department of Pediatrics, George Washington University, WA, District of Columbia, USA.
⁸ Division of Pediatrics, Wilhelmina Children's Hospital (part of UMC Utrecht), Utrecht, Netherlands.
⁹ Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada; Department of Pharmacy, The Hospital for Sick Children, Toronto, ON, Canada.
¹⁰ Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada; Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada. Electronic address: lillian.sung@sickkids.ca.

PMID: 29458789
DOI: 10.1016/j.critrevonc.2017.12.011

Meta-Analysis

Physical activity reduces fatigue in patients with cancer and hematopoietic stem cell transplant recipients: A systematic review and meta-analysis of randomized trials

Sapna Oberoi et al. Crit Rev Oncol Hematol. 2018 Feb.

. 2018 Feb:122:52-59.

doi: 10.1016/j.critrevonc.2017.12.011. Epub 2017 Dec 16.

Authors

Affiliations

¹ Pediatric Oncology Group of Ontario, Toronto, ON, Canada.
² Department of Pediatric Psychology, Children's Hospital, London Health Sciences Centre, London, ON, Canada.
³ Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada.
⁴ Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada.
⁵ Centre for Outcomes and Experiences Research in Children's Health, Illness, and Disability, Great Ormond Street Hospital for Children NHS Foundation Trust, London, School of Health Sciences, University of Surrey, Guildford, UK.
⁶ University Hospital Essen, Center for Child and Adolescent Medicine, Department of Pediatric Hematology/Oncology, Essen, Germany.
⁷ Department of Nursing Science, Professional Practice, and Quality, Children's National Health System, WA, District of Columbia, USA; Department of Pediatrics, George Washington University, WA, District of Columbia, USA.
⁸ Division of Pediatrics, Wilhelmina Children's Hospital (part of UMC Utrecht), Utrecht, Netherlands.
⁹ Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada; Department of Pharmacy, The Hospital for Sick Children, Toronto, ON, Canada.
¹⁰ Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada; Division of Haematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada. Electronic address: lillian.sung@sickkids.ca.

PMID: 29458789
DOI: 10.1016/j.critrevonc.2017.12.011

Abstract

Purpose: Objective was to determine whether physical activity reduces the severity of fatigue in patients with cancer or hematopoietic stem cell transplant (HSCT) recipients.

Methods: We conducted a meta-analysis of randomized trials comparing physical activity with control interventions for the management of fatigue in patients with cancer or HSCT recipients.

Results: There were 170 trials included. Physical activity reduced the severity of fatigue when compared to all control groups (standardized mean difference -0.49, 95% confidence interval -0.60 to -0.37; P < 0.00001). Aerobic, neuromotor, resistance and combination exercises were all effective in reducing fatigue although smaller effects were observed with resistance exercises (P interaction = 0.01). Other intervention and patient characteristics did not influence the effect of physical activity on the severity of fatigue.

Conclusions: Physical activity was effective at reducing fatigue in patients with cancer and HSCT recipients across patient sub-groups. Determining the best approaches for safe implementation should be a priority.

Keywords: Cancer; Exercise; Fatigue; Meta-analysis; Physical activity; Randomized trial.

PubMed Disclaimer

Publication types

Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- ClinicalKey
- Elsevier Science
Other Literature Sources
- scite Smart Citations
Medical

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Physical activity reduces fatigue in patients with cancer and hematopoietic stem cell transplant recipients: A systematic review and meta-analysis of randomized trials

Affiliations

Physical activity reduces fatigue in patients with cancer and hematopoietic stem cell transplant recipients: A systematic review and meta-analysis of randomized trials

Authors

Affiliations

Abstract

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical