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Meta-Analysis
. 2018 Mar;50(3):362-367.
doi: 10.1038/s41588-018-0056-5. Epub 2018 Feb 19.

Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals

Aniek C Bouwman  1 , Hans D Daetwyler  2   3 , Amanda J Chamberlain  2 , Carla Hurtado Ponce  2   4 , Mehdi Sargolzaei  5   6 , Flavio S Schenkel  5 , Goutam Sahana  7 , Armelle Govignon-Gion  8 , Simon Boitard  9 , Marlies Dolezal  10 , Hubert Pausch  2   11   12 , Rasmus F Brøndum  7 , Phil J Bowman  2 , Bo Thomsen  9 , Bernt Guldbrandtsen  7 , Mogens S Lund  7 , Bertrand Servin  13 , Dorian J Garrick  14 , James Reecy  14 , Johanna Vilkki  15 , Alessandro Bagnato  16 , Min Wang  2   3 , Jesse L Hoff  17 , Robert D Schnabel  17 , Jeremy F Taylor  17 , Anna A E Vinkhuyzen  18   19 , Frank Panitz  9 , Christian Bendixen  9 , Lars-Erik Holm  9 , Birgit Gredler  20 , Chris Hozé  8   21 , Mekki Boussaha  8 , Marie-Pierre Sanchez  8 , Dominique Rocha  8 , Aurelien Capitan  8   21 , Thierry Tribout  8 , Anne Barbat  8 , Pascal Croiseau  8 , Cord Drögemüller  22 , Vidhya Jagannathan  22 , Christy Vander Jagt  2 , John J Crowley  23 , Anna Bieber  24 , Deirdre C Purfield  25 , Donagh P Berry  25 , Reiner Emmerling  26 , Kay-Uwe Götz  26 , Mirjam Frischknecht  20 , Ingolf Russ  27 , Johann Sölkner  28 , Curtis P Van Tassell  29 , Ruedi Fries  11 , Paul Stothard  30 , Roel F Veerkamp  1 , Didier Boichard  8 , Mike E Goddard  2   4 , Ben J Hayes  31   32
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Free article
Meta-Analysis

Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals

Aniek C Bouwman et al. Nat Genet. 2018 Mar.
Free article

Abstract

Stature is affected by many polymorphisms of small effect in humans 1 . In contrast, variation in dogs, even within breeds, has been suggested to be largely due to variants in a small number of genes2,3. Here we use data from cattle to compare the genetic architecture of stature to those in humans and dogs. We conducted a meta-analysis for stature using 58,265 cattle from 17 populations with 25.4 million imputed whole-genome sequence variants. Results showed that the genetic architecture of stature in cattle is similar to that in humans, as the lead variants in 163 significantly associated genomic regions (P < 5 × 10-8) explained at most 13.8% of the phenotypic variance. Most of these variants were noncoding, including variants that were also expression quantitative trait loci (eQTLs) and in ChIP-seq peaks. There was significant overlap in loci for stature with humans and dogs, suggesting that a set of common genes regulates body size in mammals.

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References

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