Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jul;34(7):2076-2083.
doi: 10.1519/JSC.0000000000002502.

Effect of Ibuprofen on Muscle, Hematological and Renal Function, Hydric Balance, Pain, and Performance During Intense Long-Distance Running

Raphael Fabricio de Souza  1   2   3   4 , Dihogo Gama de Matos  2 , Alexandre Reis Pires Ferreira  1   2 , Philip Chilibeck  5 , Natalie de Almeida Barros  2   6 , Alan Santos Oliveira  7 , Luana Mendonça Cercato  7 , Danielle Soares da Silva  8 , Felipe José Aidar  1   2   3   6   9
Affiliations

Effect of Ibuprofen on Muscle, Hematological and Renal Function, Hydric Balance, Pain, and Performance During Intense Long-Distance Running

Raphael Fabricio de Souza et al. J Strength Cond Res. 2020 Jul.

Abstract

de Souza, RF, de Matos, DG, Ferreira, ARP, Chilibeck, P, Barros, NdA, de Oliveira, AS, Cercato, LM, da Silva, DS, and Aidar, FJ. Effect of ibuprofen on muscle, hematological and renal function, hydric balance, pain, and performance during intense long-distance running. J Strength Cond Res 34(7): 2076-2083, 2020-The aim of this study was to investigate the effect of prophylactic use of nonsteroidal anti-inflammatory drugs (i.e., ibuprofen) on physical performance, vertical jump, muscle biomarkers, liver, kidney, acute pain, and hydration status of participants in the 42-km Trail Running Challenge, a long-distance race integrated over mountain routes. The sample consisted of 20 men randomly divided into 2 groups: a control group (CG) and an experimental group (EG), with 12 completing the race (41.1 ± 8.8 years; 75.7 ± 12.1 kg) and included in the final analysis. The EG were administered an ibuprofen capsule (400 mg) 15 minutes before the beginning of the race and again after 5 hours of racing if the route was not yet completed. There were significant time main effects for creatine kinase (p = 0.001; f Cohen = 0.25), lactate dehydrogenase (p < 0.001; f Cohen = 2.05), aspartate aminotransferase (p = 0.002; f Cohen = 1.53), creatinine (p = 0.002; f Cohen = 2.24), urea (p = 0.001; f Cohen = 2.25), heart rate (p < 0.001; f Cohen = 4.88), and pain scores (p < 0.001; f Cohen = 1.93) all of which increased during the race. There was a group × time interaction for squat jump, which significantly decreased only in the CG (p = 0.045; f Cohen = 2.17). This may have been related to increased frequency of pain reported after the race in the gastrocnemius of the CG compared with the EG (p ≤ 0.05). It was concluded that ibuprofen intake did not reduce muscle damage during the competition but maintained leg muscular power performance (i.e., vertical jump), possibly by reducing gastrocnemius muscle pain.

PubMed Disclaimer

References

    1. Alexander CM, Teller LE, Gross JB. Principles of pulse oximetry: Theoretical and practical consideration. Ansesth Analg 68: 368–376, 1989.
    1. Bosco C, Luhtanen P, Komi PV. A simple method for measurement of mechanical power in jumping. Eur J Appl Physiol Occup Physiol 50: 273–282, 1983.
    1. Burke LM, Hawley JA. Fluid balance in team sports: Guidelines for optimal practices. J Sports Med 24: 38–54, 1997.
    1. Clive DM, Stroff JS. Renal syndromes associated with nonsteroid anti-inflammatory drugs. N Engl J Med 310: 563–572, 1984.
    1. Comassi M, Vitolo E, Pratali L, Del Turco S, Dellanoce C, Rossi C. Acute effects of different degrees of ultra-endurance exercise on systemic inflammatory responses. Intern Med J 45: 74–79, 2014.

Substances