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Comment
. 2018 Jul;84(7):1620-1621.
doi: 10.1111/bcp.13538. Epub 2018 Feb 21.

Was 4β-hydroxycholesterol ever going to be a useful marker of CYP3A4 activity?

Sibylle Neuhoff  1 , Geoffrey T Tucker  2
Affiliations
Comment

Was 4β-hydroxycholesterol ever going to be a useful marker of CYP3A4 activity?

Sibylle Neuhoff et al. Br J Clin Pharmacol. 2018 Jul.
No abstract available

Keywords: 4β-hydroxycholesterol; CYP3A4; biomarker.

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References

    1. Gjestad C, Haslemo T, Andreassen OA, Molden E. 4β‐Hydroxycholesterol level significantly correlates with steady‐state serum concentration of the CYP3A4 substrate quetiapine in psychiatric patients. Br J Clin Pharmacol 2017; 83: 2398–2405. - PMC - PubMed
    1. Vanhove T, Hasan M, Annaert P, Oswald S, Kuypers DRJ. Pretransplant 4β‐hydroxycholesterol does not predict tacrolimus exposure or dose requirements during the first days after kidney transplantation. Br J Clin Pharmacol 2017; 83: 2406–2415. - PMC - PubMed
    1. Diczfalusy U, Kanebratt KP, Bredberg E, Andersson TB, Bottiger Y, Bertilsson L. 4β‐Hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half‐life of elimination after induction with rifampicin. Br J Clin Pharmacol 2009; 67: 38–43. - PMC - PubMed
    1. Tomalik‐Scharte D, Lutjohann D, Doroshyenko O, Frank D, Jetter A, Fuhr U. Plasma 4β‐hydroxycholesterol: an endogenous CYP3A metric? Clin Pharmacol Ther 2009; 86: 147–153. - PubMed
    1. Bodin K, Andersson U, Rystedt E, Ellis E, Norlin M, Pikuleva I, et al Metabolism of 4β‐hydroxycholesterol in humans. J Biol Chem 2002; 277: 31534–31540. - PubMed

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