Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 May;22(5):2528-2535.
doi: 10.1111/jcmm.13418. Epub 2018 Feb 21.

Effect of caloric restriction on depression

Stephen Malunga Manchishi  1   2 , Ran Ji Cui  1 , Xiao Han Zou  1 , Zi Qian Cheng  1 , Bing Jin Li  1
Affiliations
Review

Effect of caloric restriction on depression

Stephen Malunga Manchishi et al. J Cell Mol Med. 2018 May.

Abstract

Recently, most of evidence shows that caloric restriction could induce antidepressant-like effects in animal model of depression. Based on studies of the brain-gut axis, some signal pathways were common between the control of caloric restriction and depression. However, the specific mechanism of the antidepressant-like effects induced by caloric restriction remains unclear. Therefore, in this article, we summarized clinical and experimental studies of caloric restriction on depression. This review may provide a new therapeutic strategy for depression.

Keywords: BDNF; antidepressant; calorie restriction; fasting.

PubMed Disclaimer

References

    1. Zhang Y, Liu C, Zhao Y, et al The effects of calorie restriction in depression and potential mechanisms. Curr Neuropharmacol. 2015; 13: 536–42. - PMC - PubMed
    1. Fan J, Li BJ, Wang XF, et al Ghrelin produces antidepressant‐like effect in the estrogen deficient mice. Oncotarget. 2017; 8(35): 58964–73. https://doi.org/10.18632/oncotarget.19768. - DOI - PMC - PubMed
    1. Cui R, Fan J, Ge T, et al The mechanism of acute fasting‐induced antidepressant‐like effects in mice. J Cell Mol Med. 2017; https://doi.org/10.1111/jcmm.13310. - DOI - PMC - PubMed
    1. Li B, Ge T, Cui R. Long‐term plasticity in amygdala circuits: implication of CB1‐dependent LTD in stress. Mol Neurobiol. 2017; https://doi.org/10.1007/s12035-017-0643-y. - DOI - PubMed
    1. Fan J, Li B, Ge T, et al Berberine produces antidepressant‐like effects in ovariectomized mice. Sci Rep. 2017; 7: 1310 https://doi.org/10.1038/s41598-017-01035-5. - DOI - PMC - PubMed

Publication types

Substances