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. 2018 Jun;71(6):609-612.
doi: 10.1038/s41429-018-0033-3. Epub 2018 Feb 21.

Fluvirucin B6, a new macrolactam isolated from a marine-derived actinomycete of the genus Nocardiopsis

Alain S Leutou  1 , Inho Yang  1 , Tu Cam Le  1 , Dongyup Hahn  2   3 , Kyung-Min Lim  4 , Sang-Jip Nam  5 , William Fenical  6
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Fluvirucin B6, a new macrolactam isolated from a marine-derived actinomycete of the genus Nocardiopsis

Alain S Leutou et al. J Antibiot (Tokyo). 2018 Jun.

Abstract

A new 14-membered macrolactam natural product, fluvirucin B6 (1), was isolated from a marine-derived actinomycete, Nocardiopsis sp. CNQ-115, via HPLC-UV guided isolation. The chemical structure of 1 was elucidated by 1D and 2D NMR spectroscopic data analysis. Compound 1 showed a weak activity against Gram-positive bacteria, whereas it was inactive against Gram-negative bacteria.

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