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Comment
. 2018 Feb 7:9:21.
doi: 10.3389/fgene.2018.00021. eCollection 2018.

Commentary: Programmable base editing of A·T to G·C in genomic DNA without DNA cleavage

Ianis G Matsoukas  1
Affiliations
Comment

Commentary: Programmable base editing of A·T to G·C in genomic DNA without DNA cleavage

Ianis G Matsoukas. Front Genet. .
No abstract available

Keywords: CRISPR; Cas-9; base editing; genome engineering; targeted gene repair.

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Figures

Figure 1
Figure 1
The Structure of the Adenine Base Editor (ABE). The ABE contains an atom-rearranging enzyme (in red) that can convert adenine to inosine (read and copied as guanine), sgRNA (in green), which directs the molecule to the desired point, and a Cas9 nickase (in blue), which snips the opposing strand of DNA and tricks the cell into converting the complementary base (Gaudelli et al., 2017).
See this image and copyright information in PMC

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