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. 2018 May;24(5):943-946.
doi: 10.3201/eid2405.171935. Epub 2018 May 17.

Multiple Introductions of Influenza A(H5N8) Virus into Poultry, Egypt, 2017

Ahmed H Salaheldin, Abd El-Hamid, Ahmed R Elbestawy, Jutta Veits, Hafez M Hafez, Thomas C Mettenleiter, Elsayed M Abdelwhab

Multiple Introductions of Influenza A(H5N8) Virus into Poultry, Egypt, 2017

Ahmed H Salaheldin et al. Emerg Infect Dis. 2018 May.

Abstract

After high mortality rates among commercial poultry were reported in Egypt in 2017, we genetically characterized 4 distinct influenza A(H5N8) viruses isolated from poultry. Full-genome analysis indicated separate introductions of H5N8 clade 2.3.4.4 reassortants from Europe and Asia into Egypt, which poses a serious threat for poultry and humans.

Keywords: Africa; Egypt; H5N8; clade 2.3.4.4; domestic birds; ducks; highly pathogenic avian influenza virus; influenza; migratory birds; viruses.

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Figures

Figure
Figure
Characterization of highly pathogenic avian influenza A(H5N8) viruses of clade 2.3.4.4 from Egypt, 2017. A) Phylogenetic relatedness of the HA gene and schematic representation of potential precursors of different H5N8 viruses. The maximum-likelihood midpoint rooted tree was constructed by using MrBayes (http://mrbayes.sourceforge.net/). Red indicates viruses from this study. Scale bar indicates nucleotide substitutions per site. B) Putative ancestors of the different gene segments of H5N8 viruses from Egypt characterized in this study compared with reference viruses. C) Governorates in Egypt where H5N8 viruses had been reported in domestic birds (circles) and where viruses in birds had been previously reported (stars). Inset shows study location in Egypt. Ck, chicken farm; Dk, duck farm; HA, hemagglutinin; M, matrix; NA, neuraminidase; NP, nucleocapsid protein; NS, nonstructural; PA, polymerase acidic; PB, polymerase basic.
See this image and copyright information in PMC

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