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. 2013 Feb 6;2(1):2.
doi: 10.1186/2194-0517-2-2.

Evaluation of polyphenylene ether ether sulfone/nanohydroxyapatite nanofiber composite as a biomaterial for hard tissue replacement

Manickam Ashokkumar  1 , Dharmalingam Sangeetha  2
Affiliations

Evaluation of polyphenylene ether ether sulfone/nanohydroxyapatite nanofiber composite as a biomaterial for hard tissue replacement

Manickam Ashokkumar et al. Prog Biomater. .

Abstract

The present work is aimed at investigating the mechanical and in vitro biological properties of polyphenylene ether ether sulfone (PPEES)/nanohydroxyapatite (nHA) composite fibers. Electrospinning was used to prepare nanofiber composite mats of PPEES/nHA with different weight percentages of the inorganic filler, nHA. The fabricated composites were characterized using Fourier transform infrared spectroscopy (FTIR)-attenuated total reflectance spectroscopy (ATR) and scanning electron microscopy (SEM)-energy dispersive X-ray spectroscopy (EDX) techniques. The mechanical properties of the composite were studied with a tensile tester. The FTIR-ATR spectrum depicted the functional group as well as the interaction between the PPEES and nHA composite materials; in addition, the elemental groups were identified with EDX analysis. The morphology of the nanofiber composite was studied by SEM. Tensile strength analysis of the PPEES/nHA composite revealed the elastic nature of the nanofiber composite reinforced with nHA and suggested significant mechanical strength of the composite. The biomineralization studies performed using simulated body fluid with increased incubation time showed enhanced mineralization, which showed that the composites possessed high bioactivity property. Cell viability of the nanofiber composite, studied with osteoblast (MG-63) cells, was observed to be higher in the composites containing higher concentrations of nHA.

Keywords: Bioactivity; Biomineralization; Nanohydroxyapatite; Osteoblast cells; Polyphenylene ether ether sulfone.

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Figures

Figure 1
Figure 1
FTIR-ATR spectra of PPEES nanofiber and its composite: ( curve a ) PPEES nanofiber, ( curve b ) PPEES 1, ( curve c ) PPEES 2, and ( curve d ) PPEES 3.
Figure 2
Figure 2
SEM images showing surface morphology (a–c) and cross-sectional images (d–f) of PPEES and its composite. (a) PPEES, (b) PPEES 2, (c) PPEES 3, (d) PPEES, (e) PPEES 2, and (f) PPEES 3.
Figure 3
Figure 3
SEM image showing the surface morphology of PPEES and its composites after incubation in SBF. (a) PPEES after 30 days, (b) PPEES 2 after 5 days, (c) PPEES 2 after 15 days, and (d) PPEES 2 after 30 days of incubation in SBF.
Figure 4
Figure 4
EDX profile of biomineralization of PPEES 2 composite (a) before, (b) after 15 days, and (c) after 30 days of incubation in SBF.
Figure 5
Figure 5
Percentage viability of osteoblast (MG-63) cells on PPEES 2 nanofiber composites.
Figure 6
Figure 6
Inverted fluorescence microscopy images after 3-, 7-, and 10-day cultures of PPEES nanofiber (a–c) and PPEES2 nanofiber (d–f) composites.
Figure 7
Figure 7
Cell differentiation of osteoblast on PPEES nanofiber and its composite.
See this image and copyright information in PMC

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