Review

. 2018 Jul;24(7):1322-1340.

doi: 10.1016/j.bbmt.2018.02.009. Epub 2018 Feb 19.

The Microbiome and Hematopoietic Cell Transplantation: Past, Present, and Future

Tessa M Andermann¹, Jonathan U Peled², Christine Ho³, Pavan Reddy⁴, Marcie Riches⁵, Rainer Storb⁶, Takanori Teshima⁷, Marcel R M van den Brink⁸, Amin Alousi⁹, Sophia Balderman¹⁰, Patrizia Chiusolo¹¹, William B Clark¹², Ernst Holler¹³, Alan Howard¹⁴, Leslie S Kean¹⁵, Andrew Y Koh¹⁶, Philip L McCarthy³, John M McCarty¹⁷, Mohamad Mohty¹⁸, Ryotaro Nakamura¹⁹, Katy Rezvani²⁰, Brahm H Segal²¹, Bronwen E Shaw²², Elizabeth J Shpall²³, Anthony D Sung²⁴, Daniela Weber¹³, Jennifer Whangbo²⁵, John R Wingard²⁶, William A Wood²⁷, Miguel-Angel Perales², Robert R Jenq²⁸, Ami S Bhatt²⁹; Blood and Marrow Transplant Clinical Trials Network

Affiliations

¹ Division of Infectious Diseases, Department of Medicine, Stanford University, Stanford, California.
² Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Medicine, Weill Cornell Medical College, New York, New York.
³ Blood and Marrow Transplantation, Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
⁴ Department of Medicine, University of Michigan Cancer Center, Ann Arbor, Michigan.
⁵ Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
⁶ Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Medicine, University of Washington School of Medicine, Seattle, Washington.
⁷ Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan.
⁸ Immunology Program, Sloan Kettering Institute, New York, New York; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
⁹ Multidiscipline GVHD Clinic and Research Program, Department of Stem Cell Transplant and Cellular Therapies, University of Texas, MD Anderson Cancer Center, Houston, Texas.
¹⁰ Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
¹¹ Hematology Department, Fondazione Policlinico Universitario A. Gemelli, Università Cattolica Sacro Cuore, Rome, Italy.
¹² Bone Marrow Transplant Program, Division of Hematology/Oncology and Palliative Care, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia.
¹³ Department of Internal Medicine 3, University Medical Center, Regensburg, Germany.
¹⁴ Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota.
¹⁵ Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, Washington.
¹⁶ Divisions of Hematology/Oncology and Infectious Diseases, Departments of Pediatrics and Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas.
¹⁷ Bone Marrow Transplantation Program, Virginia Commonwealth University Massey Cancer, Richmond, Virginia.
¹⁸ Clinical Hematology and Cellular Therapy Department, Hôpital Saint-Antoine, AP-HP, Paris, France; Sorbonne Université, Paris, France; INSERM UMRs U938, Paris, France.
¹⁹ Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, California.
²⁰ Section of Cellular Therapy, Good Manufacturing Practices Facility, Department of Stem Cell Transplant and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas.
²¹ Department of Medicine, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York; Division of Infectious Diseases, Roswell Park Comprehensive Cancer Center, Buffalo, New York; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
²² Center for International Blood and Bone Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin.
²³ Cell Therapy Laboratory and Cord Blood Bank, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas, MD Anderson Cancer Center, Houston, Texas.
²⁴ Division of Hematologic Malignancies and Cellular Therapy, Duke University School of Medicine, Duke Cancer Institute, Durham, North Carolina.
²⁵ Dana-Farber Cancer Institute, Boston Children's Hospital, Boston, Massachusetts.
²⁶ Department of Medicine, University of Florida Health Cancer Center, Gainesville, Florida; Bone Marrow Transplant Program, Division of Hematology/Oncology, University of Florida College of Medicine, Florida.
²⁷ Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
²⁸ Departments of Genomic Medicine and Stem Cell Transplantation Cellular Therapy, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address: rrjenq@mdanderson.org.
²⁹ Department of Genetics and Division of Hematology, Department of Medicine, Stanford University, Stanford, California. Electronic address: asbhatt@stanford.edu.

PMID: 29471034
PMCID: PMC6045977
DOI: 10.1016/j.bbmt.2018.02.009

Review

The Microbiome and Hematopoietic Cell Transplantation: Past, Present, and Future

Tessa M Andermann et al. Biol Blood Marrow Transplant. 2018 Jul.

. 2018 Jul;24(7):1322-1340.

doi: 10.1016/j.bbmt.2018.02.009. Epub 2018 Feb 19.

Authors

Affiliations

¹ Division of Infectious Diseases, Department of Medicine, Stanford University, Stanford, California.
² Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York; Department of Medicine, Weill Cornell Medical College, New York, New York.
³ Blood and Marrow Transplantation, Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
⁴ Department of Medicine, University of Michigan Cancer Center, Ann Arbor, Michigan.
⁵ Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
⁶ Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Medicine, University of Washington School of Medicine, Seattle, Washington.
⁷ Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan.
⁸ Immunology Program, Sloan Kettering Institute, New York, New York; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.
⁹ Multidiscipline GVHD Clinic and Research Program, Department of Stem Cell Transplant and Cellular Therapies, University of Texas, MD Anderson Cancer Center, Houston, Texas.
¹⁰ Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
¹¹ Hematology Department, Fondazione Policlinico Universitario A. Gemelli, Università Cattolica Sacro Cuore, Rome, Italy.
¹² Bone Marrow Transplant Program, Division of Hematology/Oncology and Palliative Care, Department of Internal Medicine, Virginia Commonwealth University, Richmond, Virginia.
¹³ Department of Internal Medicine 3, University Medical Center, Regensburg, Germany.
¹⁴ Center for International Blood and Marrow Transplant Research, Minneapolis, Minnesota.
¹⁵ Fred Hutchinson Cancer Research Center, Seattle, Washington; Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington; Ben Towne Center for Childhood Cancer Research, Seattle Children's Research Institute, Seattle, Washington.
¹⁶ Divisions of Hematology/Oncology and Infectious Diseases, Departments of Pediatrics and Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas.
¹⁷ Bone Marrow Transplantation Program, Virginia Commonwealth University Massey Cancer, Richmond, Virginia.
¹⁸ Clinical Hematology and Cellular Therapy Department, Hôpital Saint-Antoine, AP-HP, Paris, France; Sorbonne Université, Paris, France; INSERM UMRs U938, Paris, France.
¹⁹ Department of Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, California.
²⁰ Section of Cellular Therapy, Good Manufacturing Practices Facility, Department of Stem Cell Transplant and Cellular Therapy, University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas.
²¹ Department of Medicine, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York; Division of Infectious Diseases, Roswell Park Comprehensive Cancer Center, Buffalo, New York; Department of Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
²² Center for International Blood and Bone Marrow Transplant Research, Medical College of Wisconsin, Milwaukee, Wisconsin.
²³ Cell Therapy Laboratory and Cord Blood Bank, Department of Stem Cell Transplantation and Cellular Therapy, University of Texas, MD Anderson Cancer Center, Houston, Texas.
²⁴ Division of Hematologic Malignancies and Cellular Therapy, Duke University School of Medicine, Duke Cancer Institute, Durham, North Carolina.
²⁵ Dana-Farber Cancer Institute, Boston Children's Hospital, Boston, Massachusetts.
²⁶ Department of Medicine, University of Florida Health Cancer Center, Gainesville, Florida; Bone Marrow Transplant Program, Division of Hematology/Oncology, University of Florida College of Medicine, Florida.
²⁷ Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
²⁸ Departments of Genomic Medicine and Stem Cell Transplantation Cellular Therapy, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address: rrjenq@mdanderson.org.
²⁹ Department of Genetics and Division of Hematology, Department of Medicine, Stanford University, Stanford, California. Electronic address: asbhatt@stanford.edu.

PMID: 29471034
PMCID: PMC6045977
DOI: 10.1016/j.bbmt.2018.02.009

No abstract available

Keywords: Fecal microbiota transplant; Hematopoietic stem cell transplantation; Metagenomics; Microbiome; Microbiota; Prebiotic.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest

No conflicts of interest to report: TMA, CH, PR, MLR, RS, TT, AA, SB, PC, WBC, EH, AH, AYK, PLM, JMM, RN, KR, BES, EJS, ADS, DW, JW, JRW, WAW, MAP, ASB

Seres Therapeutics Inc: JUP (licensing fees and research support), MRMVDB (research support), RRJ (advisory committee, holds patents with or receives royalties)

Figures

**Figure 1**
Structuring the design of future interventions aimed at establishing microbe-host disease causality

See this image and copyright information in PMC

Cited by

Novel Biomarkers for Outcome After Allogeneic Hematopoietic Stem Cell Transplantation.
Chen S, Zeiser R. Chen S, et al. Front Immunol. 2020 Aug 18;11:1854. doi: 10.3389/fimmu.2020.01854. eCollection 2020. Front Immunol. 2020. PMID: 33013836 Free PMC article. Review.
Microbiome: An Emerging New Frontier in Graft-Versus-Host Disease.
Kumari R, Palaniyandi S, Hildebrandt GC. Kumari R, et al. Dig Dis Sci. 2019 Mar;64(3):669-677. doi: 10.1007/s10620-018-5369-9. Epub 2018 Dec 7. Dig Dis Sci. 2019. PMID: 30523482 Review.
Sarcopenia and gut microbiota alterations in patients with hematological diseases before and after hematopoietic stem cell transplantation.
Wang B, Hu W, Zhang X, Cao Y, Shao L, Xu X, Liu P. Wang B, et al. Chin J Cancer Res. 2023 Aug 30;35(4):386-398. doi: 10.21147/j.issn.1000-9604.2023.04.05. Chin J Cancer Res. 2023. PMID: 37691890 Free PMC article.
The gut microbiome: an important factor influencing therapy for pediatric acute lymphoblastic leukemia.
Xu Y, Gao H, Li H. Xu Y, et al. Ann Hematol. 2024 Aug;103(8):2621-2635. doi: 10.1007/s00277-023-05480-3. Epub 2023 Sep 29. Ann Hematol. 2024. PMID: 37775598 Review.
Post-haematopoietic cell transplantation outcomes: why ST2 became a 'golden nugget' biomarker.
Paczesny S. Paczesny S. Br J Haematol. 2021 Mar;192(6):951-967. doi: 10.1111/bjh.16497. Epub 2020 Feb 10. Br J Haematol. 2021. PMID: 32039480 Free PMC article. Review.

See all "Cited by" articles

References

1. Taur Y, Jenq RR, Perales M-A, et al. The effects of intestinal tract bacterial diversity on mortality following allogeneic hematopoietic stem cell transplantation. Blood. 2014;124(7):1174–1182. doi: 10.1182/blood-2014-02-554725. - DOI - PMC - PubMed
1. Peled JU, Devlin SM, Staffas A, et al. Intestinal Microbiota and Relapse After Hematopoietic-Cell Transplantation. J Clin Oncol Off J Am Soc Clin Oncol. 2017;35(15):1650–1659. doi: 10.1200/JCO.2016.70.3348. - DOI - PMC - PubMed
1. Holler E, Butzhammer P, Schmid K, et al. Metagenomic analysis of the stool microbiome in patients receiving allogeneic stem cell transplantation: loss of diversity is associated with use of systemic antibiotics and more pronounced in gastrointestinal graft-versus-host disease. Biol Blood Marrow Transplant J Am Soc Blood Marrow Transplant. 2014;20(5):640–645. doi: 10.1016/j.bbmt.2014.01.030. - DOI - PMC - PubMed
1. Connell MS, Wilson R. THE TREATMENT OF X-IRRADIATED GERMFREE CFW AND C3H MICE WITH ISOLOGOUS AND HOMOLOGOUS BONE MARROW. Life Sci. 1965;4:721–729. - PubMed
1. Jones JM, Wilson R, Bealmear PM. Mortality and gross pathology of secondary disease in germfree mouse radiation chimeras. Radiat Res. 1971;45(3):577–588. - PubMed

Publication types

Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Miscellaneous
- NCI CPTAC Assay Portal

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

The Microbiome and Hematopoietic Cell Transplantation: Past, Present, and Future

Affiliations

The Microbiome and Hematopoietic Cell Transplantation: Past, Present, and Future

Authors

Affiliations

Conflict of interest statement

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Miscellaneous