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. 2018 Jun:136:59-64.
doi: 10.1016/j.apradiso.2018.02.002. Epub 2018 Feb 10.

Clinical experience with indigenous kit-based preparation of 68Ga-DOTATOC using commercial 68Ge/68Ga generator

Usha Pandey  1 , Aruna Korde  2 , Archana Mukherjee  1 , Ajit Shinto  3 , K K Kamaleswaran  3 , Raghi P Jose  3 , Naresh Gamre  4 , Ashutosh Dash  1
Affiliations

Clinical experience with indigenous kit-based preparation of 68Ga-DOTATOC using commercial 68Ge/68Ga generator

Usha Pandey et al. Appl Radiat Isot. 2018 Jun.

Abstract

Pharmaceutical grade DOTATOC kits compliant with all the quality control criteria were formulated and radiolabeled with 68Ga in high yields. Comparison with module-based 68Ga-DOTATOC established product equivalency. Clinical utility was evaluated in patients with histopathologically confirmed well-differentiated neuroendocrine tumors. Kit-based preparation of 68Ga-DOTATOC could identify sites of primary and metastatic disease. PET/CT images of patients conformed to the established criteria for somatostatin imaging agents and clinical expectations. Results of this study emphasize the potential of kit-based 68Ga-DOTATOC for PET imaging of neuroendocrine tumors.

Keywords: (68)Ga; (68)Ge/(68)Ga generator; DOTATOC kits; Neuroendocrine tumors; Somatostatin.

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