Calcitonin gene-related peptide (receptor) antibodies: an exciting avenue for migraine treatment
- PMID: 29471874
- PMCID: PMC5824555
- DOI: 10.1186/s13073-018-0524-7
Calcitonin gene-related peptide (receptor) antibodies: an exciting avenue for migraine treatment
Abstract
Specific prophylactic migraine treatments are urgently needed because of the unmet needs of many migraine patients. Antibodies targeting calcitonin gene-related peptide (CGRP) or its receptor have recently shown efficacy in episodic and chronic migraine and will be available soon.
Conflict of interest statement
Competing interests
AMVDB has obtained research grants from Amgen/Novartis and Lilly. GMT reports consultancy support from Novartis and Lilly. AMJMvdM declares that he has no competing interests.
Publisher’s Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Similar articles
-
Therapeutic antibodies against CGRP or its receptor.Br J Clin Pharmacol. 2015 Jun;79(6):886-95. doi: 10.1111/bcp.12591. Br J Clin Pharmacol. 2015. PMID: 25614243 Free PMC article. Review.
-
Calcitonin gene-related peptide (CGRP) and migraine current understanding and state of development.Headache. 2013 Sep;53(8):1230-44. doi: 10.1111/head.12179. Epub 2013 Jul 12. Headache. 2013. PMID: 23848260 Review.
-
CGRP and Migraine: The Role of Blocking Calcitonin Gene-Related Peptide Ligand and Receptor in the Management of Migraine.Drugs. 2018 Jun;78(9):913-928. doi: 10.1007/s40265-018-0923-5. Drugs. 2018. PMID: 29869205 Review.
-
Erenumab in the treatment of migraine.Pain Manag. 2018 Nov 1;8(6):415-426. doi: 10.2217/pmt-2018-0037. Epub 2018 Sep 21. Pain Manag. 2018. PMID: 30235976 Review.
-
Patent watch: Migraine therapies targeting the CGRP pathway: intellectual property landscape.Nat Rev Drug Discov. 2016 Jan;15(1):8-9. doi: 10.1038/nrd.2015.11. Epub 2015 Dec 16. Nat Rev Drug Discov. 2016. PMID: 26669672 No abstract available.
Cited by
-
Interplay between cannabinoids and the neuroimmune system in migraine.J Headache Pain. 2024 Oct 16;25(1):178. doi: 10.1186/s10194-024-01883-3. J Headache Pain. 2024. PMID: 39407099 Free PMC article. Review.
-
Serotonergic Modulation of Neurovascular Transmission: A Focus on Prejunctional 5-HT Receptors/Mechanisms.Biomedicines. 2023 Jun 29;11(7):1864. doi: 10.3390/biomedicines11071864. Biomedicines. 2023. PMID: 37509503 Free PMC article. Review.
-
The role of erenumab in the treatment of migraine.Ther Adv Neurol Disord. 2020 May 27;13:1756286420927119. doi: 10.1177/1756286420927119. eCollection 2020. Ther Adv Neurol Disord. 2020. PMID: 32523630 Free PMC article. Review.
-
Vascular safety of erenumab for migraine prevention.Neurology. 2020 Feb 4;94(5):e497-e510. doi: 10.1212/WNL.0000000000008743. Epub 2019 Dec 18. Neurology. 2020. PMID: 31852816 Free PMC article.
-
Recent Development of Zolmitriptan Formulation in Migraine Therapy: Production, Metabolism and Pharmaceutical Aspects.CNS Neurol Disord Drug Targets. 2025;24(3):219-233. doi: 10.2174/0118715273306929240820071521. CNS Neurol Disord Drug Targets. 2025. PMID: 39279695 Review.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials