Review
doi: 10.1016/j.tcm.2018.01.001.
Epub 2018 Jan 9.
Heart failure with preserved ejection fraction: Classification based upon phenotype is essential for diagnosis and treatment
Affiliations
- PMID: 29471985
- DOI: 10.1016/j.tcm.2018.01.001
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Review
Heart failure with preserved ejection fraction: Classification based upon phenotype is essential for diagnosis and treatment
Trends Cardiovasc Med.
2018 Aug.
Abstract
Heart failure (HF) is classified based upon the left ventricular ejection fraction (LVEF). Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous disorder with increasing prevalence in the elderly that remains incompletely understood and inadequately treated as no therapy has shown favorable effects. In this review, we summarize the current theories regarding HFpEF pathogenesis, propose a phenotype-based classification of HFpEF, discuss prevention strategies, explain why clinical trials on HFpEF treatment have failed, and make suggestions for the future.
Keywords: Classification; Heart failure; Phenotypes; Preserved ejection fraction.
Copyright © 2018 Elsevier Inc. All rights reserved.
Comment in
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Editorial commentary: Heart failure with preserved ejection fraction-Clinical syndrome with incomplete understanding.Trends Cardiovasc Med. 2018 Aug;28(6):401-402. doi: 10.1016/j.tcm.2018.01.005. Epub 2018 Feb 2. Trends Cardiovasc Med. 2018. PMID: 29428158 No abstract available.
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