Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Aug;28(6):392-400.
doi: 10.1016/j.tcm.2018.01.001. Epub 2018 Jan 9.

Heart failure with preserved ejection fraction: Classification based upon phenotype is essential for diagnosis and treatment

Andrew Xanthopoulos  1 , Filippos Triposkiadis  2 , Randall C Starling  3
Affiliations
Review

Heart failure with preserved ejection fraction: Classification based upon phenotype is essential for diagnosis and treatment

Andrew Xanthopoulos et al. Trends Cardiovasc Med. 2018 Aug.

Abstract

Heart failure (HF) is classified based upon the left ventricular ejection fraction (LVEF). Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous disorder with increasing prevalence in the elderly that remains incompletely understood and inadequately treated as no therapy has shown favorable effects. In this review, we summarize the current theories regarding HFpEF pathogenesis, propose a phenotype-based classification of HFpEF, discuss prevention strategies, explain why clinical trials on HFpEF treatment have failed, and make suggestions for the future.

Keywords: Classification; Heart failure; Phenotypes; Preserved ejection fraction.

PubMed Disclaimer

Comment in

LinkOut - more resources