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Case Reports
. 2018 Mar;40(3):198-200.
doi: 10.1097/DAD.0000000000000862.

Ibrutinib-Induced Neutrophilic Dermatosis

Layal El Halabi  1 , Khadija Cherif-Rebai  2 , Jean-Marie Michot  1 , David Ghez  1
Affiliations
Case Reports

Ibrutinib-Induced Neutrophilic Dermatosis

Layal El Halabi et al. Am J Dermatopathol. 2018 Mar.

Abstract

We report the case of a 64-year-old woman treated with ibrutinib for a chronic lymphocytic leukemia with 17p deletion, who developed several erythematous, painful, and papulo-nodular skin lesions in the limbs, neck, and face. The skin biopsy was consistent with the diagnosis of neutrophilic dermatosis. Rechallenge with ibrutinib at full dose was followed by the recurrence of the same skin lesions, strongly suggesting a direct relationship.

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